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How could hypoglycemia-inducing glycogen storage disease lead to hyperglycemia-induced mucormycosis?

Larry Nichols; Diana Alejandra Rios

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Mucormycosis is an increasingly frequent, difficult to diagnose, difficult to treat, often fatal infection, especially in patients with hyperglycemia from uncontrolled diabetes. Type I (von Gierke) glycogen storage disease is due to inherited deficiency of enzymes in glycogen metabolism, which causes hypoglycemia. This report is the case of a patient with von Gierke disease and a missed diagnosis of pulmonary mucormycosis. This report illustrates the importance of having a high index of suspicion for mucormycosis in the appropriate clinical context.


Mucor, Lung Diseases, Fungal, Glycogen Storage Disease Type I, Autopsy


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Glycogen storage disease type I: von Gierke disease [Internet]. Treasure Island: StatPearls Publishing; 2019 [cited 2019 Dec 17]. Available from:

















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