Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2024.510
Autopsy and Case Reports
Clinical Case Report and Review

Unravelling the mystery of the central dentinogenic ghost cell tumor- a rare case report and recurrent insights

Jagveer Yadav; Mala Kamboj; Anju Devi; Anjali Narwal; Deepti Chhikara; Bhawna Saini

Downloads: 0
Views: 139

Abstract

Dentinogenic ghost cell tumor (DGCT) is a rare benign neoplasm form of calcifying odontogenic cyst (COC) characterized by ghost cells. Although benign, it presents an aggressive behavior. DGCT accounts for 2% to 14% of all COCs and less than 0.5% of all odontogenic tumors. It is a benign odontogenic tumor despite its local invasion and the likelihood of recurrence. To detect recurrence, central DGCT patients must be monitored long-term. We present the case of a 51-year-old male who reported pain in the right upper back tooth region. On examination, a soft to firm, bright red swelling was present in the buccal vestibule and gingival margin of the maxillary right first and second molar, which extended up to the palate. Histopathological analysis confirmed the diagnosis of a DGCT, which occurred in a previously treated calcifying odontogenic cyst. The case is reported here, along with a review of the literature update of such recurred instances in the past.

Keywords

Maxillary Neoplasms, Odontogenic Cyst, Calcifying, Odontogenic Tumors

References

1 Sun G, Huang X, Hu Q, Yang X, Tang E. The diagnosis and treatment of dentinogenic ghost cell tumor. Int J Oral Maxillofac Surg. 2009;38(11):1179-83. http://doi.org/10.1016/j.ijom.2009.06.016. PMid:19619984.

2 Novembre D, Giofrè E, Barca I, Ferragina F, Cristofaro MG. A rare case of mandibular dentinogenic ghost cell tumor: Histopathological, clinical and surgical management. J Oral Maxillofac Pathol. 2021;25(1):206. http://doi.org/10.4103/jomfp.JOMFP_185_20. PMid:34349449.

3 Alzaid MA, Kavarodi AM, AlQahtani WM, AlJanobi HA. Recurrent dentinogenic ghost cell tumor: a case report. Am J Case Rep. 2022;23:e936787. http://doi.org/10.12659/AJCR.936787. PMid:35996339.

4 Gupta S, Singh S, Anjum R, Sharma R. Dentinogenic ghost-cell tumor of the maxilla: a case report and review of literature. J Oral Maxillofac Pathol. 2019;23(3):478. http://doi.org/10.4103/jomfp.JOMFP_117_19. PMid:31942143.

5 Reddy V, Wadhwan V, Singh R, Bansal V. Dentinogenic ghost cell tumor: case report of a rare central variant and literature review. J Oral Maxillofac Pathol. 2022;26(5, Suppl 1):S68-72. http://doi.org/10.4103/jomfp.jomfp_174_21. PMid:35450252.

6 Hammad Y, Bueno S, McLean-Holden A, Schlieve T. Dentinogenic ghost cell tumor: a case report and review of the literature. Oral Maxillofac Surg. 2022;27(1):169-73. http://doi.org/10.1007/s10006-021-01034-x. PMid:35098400.

7 Bussari S, Thakur SM, Koshy AV, Shah AA. Dentinogenic ghost cell tumor - a case report and review of literature. J Oral Maxillofac Pathol. 2019;23(4, Suppl 1):66-8. http://doi.org/10.4103/jomfp.JOMFP_123_18. PMid:30967728.

8 Konstantakis D, Kosyfaki P, Ebhardt H, Schmelzeisen R, Voss PJ. Intraosseous dentinogenic ghost cell tumor: a clinical report and literature update. J Craniomaxillofac Surg. 2014;42(5):e305-11. http://doi.org/10.1016/j.jcms.2013.10.011. PMid:24296117.

9 Buchner A, Akrish SJ, Vered M. Central dentinogenic ghost cell tumor: an update on a rare aggressive odontogenic tumor. J Oral Maxillofac Surg. 2016;74(2):307-14. http://doi.org/10.1016/j.joms.2015.08.001. PMid:26341683.

10 El-Naggar AK, Chan JKC, Takata T, Grandis JR, Slootweg PJ. The fourth edition of the head and neck World Health Organization blue book: editors' perspectives. Hum Pathol. 2017;66:10-12. http://doi.org/10.1016/j.humpath.2017.05.014.

11 Agrawal Y, Naidu GS, Makkad RS, et al. Dentinogenic ghost cell tumor-a rare case report with review of literature. Quant Imaging Med Surg. 2017;7(5):598-604. http://doi.org/10.21037/qims.2017.03.06. PMid:29184770.

12 Tajima Y, Ohno J, Utsumi N. The dentinogenic ghost cell tumor. J Oral Pathol. 1986;15(6):359-62. http://doi.org/10.1111/j.1600-0714.1986.tb00640.x. PMid:3093655.

13 Stone CH, Gaba AR, Benninger MS, Zarbo RJ. Odontogenic ghost cell tumor: a case report with cytologic findings. Diagn Cytopathol. 1998;18(3):199-203. http://doi.org/10.1002/(SICI)1097-0339(199803)18:3<199::AID-DC7>3.0.CO;2-9. PMid:9523138.

14 Kasahara K, Iizuka T, Kobayashi I, Totsuka Y, Kohgo T. A recurrent case of odontogenic ghost cell tumour of the mandible. Int J Oral Maxillofac Surg. 2002;31(6):684-7. http://doi.org/10.1054/ijom.2002.0239. PMid:12521331.

15 Li TJ, Yu SF. Clinicopathologic spectrum of the so-called calcifying odontogenic cysts: a study of 21 intraosseous cases with reconsideration of the terminology and classification. Am J Surg Pathol. 2003;27(3):372-84. http://doi.org/10.1097/00000478-200303000-00011. PMid:12604894.

16 Park HR, Min JH, Huh KH, et al. Distant metastasis of intraosseous dentinogenic ghost cell tumour to the donor site of a bone graft. Dentomaxillofac Radiol. 2013;42(5):20120172.; published online February 18, 2013. http://doi.org/10.1259/dmfr.20120172. PMid:23420853.

17 Biggs TC, Hayes SM, Harries PG, Salib RJ. Maxillary dentinogenic ghost cell tumour. Ann R Coll Surg Engl. 2013;95(3):e63-5. http://doi.org/10.1308/003588413X13511609957010. PMid:23827283.
 


Submitted date:
09/01/2023

Accepted date:
06/28/2024

Publication date:
08/15/2024

66be29eaa95395347462d8f4 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections