Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2024.508
Autopsy and Case Reports
Clinical Case Report

Laryngeal plasmacytoma in a patient with Down’s syndrome

Hassan Hodroj; Zahraa Saker; Zahraa Al Najjar; Hassane Choukr; Mohamad Reda Noureddine El Moussaoui

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Abstract

Extramedullary plasmacytoma is a rare localized plasma cell neoplasm typically found in soft tissues outside the bone marrow. Predominantly occurring in the head and neck region, particularly in the sinonasal and nasopharyngeal areas, it presents a diagnostic challenge due to its uncommon nature. Herein, we report a 38-year-old female patient with Down’s syndrome with a 2-year complaint of intermittent dysphonia, hoarseness, and progressive respiratory distress, including dyspnea, fatigue, and biphasic stridor. Examination via flexible laryngoscopy revealed a white lesion, prompting direct microscopic laryngeal surgery to excise a 1x1 cm mass. Histological findings confirmed the diagnosis as solitary extramedullary plasmacytoma. Notably, this represented the first documented case of laryngeal solitary extramedullary plasmacytoma in a patient with Down’s syndrome. This case underscores the importance of considering tumor development in the larynx among individuals with Down’s syndrome, highlighting the necessity for tailored management strategies to address such occurrences effectively. Increasing awareness of this association can aid in early detection and appropriate treatment of tumors in this population.

Keywords

Extramedullary plasmacytoma, laryngeal neoplasms, larynx

References

1 Rajkumar SV. Updated diagnostic criteria and staging system for multiple myeloma. Am Soc Clin Oncol Educ Book. 2016;35(36):e418-23. http://doi.org/10.1200/EDBK_159009. PMid:27249749.

2 Lai CY, Hsieh HH, Chen HK, et al. Clinical features of head and neck solitary extramedullary plasmacytoma in Taiwan. In Vivo. 2020;34(1):261-5. http://doi.org/10.21873/invivo.11769. PMid:31882487.

3 Lewis K, Thomas R, Grace R, Moffat C, Manjaly G, Howlett DC. Extramedullary plasmacytomas of the larynx and parapharyngeal space: imaging and pathologic features. Ear Nose Throat J. 2007;86(9):567-9. http://doi.org/10.1177/014556130708600913. PMid:17970149.

4 Holler A, Cicha I, Eckstein M, et al. Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts follow-up. Cancer Med. 2022;11(24):4743-55. http://doi.org/10.1002/cam4.4816. PMid:35578404.

5 Ramírez-Anguiano J, Lara-Sánchez H, Martínez-Baños D, Martínez-Benítez B. Extramedullary plasmacytoma of the larynx: a case report of subglottic localization. Case Rep Otolaryngol. 2012;2012:437264. http://doi.org/10.1155/2012/437264. PMid:23082263.

6 Wang J, Li J, Zhang F, Zhang P. Retroperitoneal extramedullary plasmacytoma: a case report and review of the literature. Medicine. 2018;97(46):e13281. http://doi.org/10.1097/MD.0000000000013281. PMid:30431616.

7 Wen G, Wang W, Zhang Y, Niu S, Li Q, Li Y. Management of extramedullary plasmacytoma: role of radiotherapy and prognostic factor analysis in 55 patients. Chin J Cancer Res. 2017;29(5):438-46. http://doi.org/10.21147/j.issn.1000-9604.2017.05.08. PMid:29142463.

8 Saad R, Raab S, Liu Y, Pollice P, Silverman JF. Plasmacytoma of the larynx diagnosed by fine-needle aspiration cytology: a case report. Diagn Cytopathol. 2001;24(6):408-11. http://doi.org/10.1002/dc.1090. PMid:11391823.

9 Soutar R, Lucraft H, Jackson G, et al. Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Br J Haematol. 2004;124(6):717-26. http://doi.org/10.1111/j.1365-2141.2004.04834.x. PMid:15009059.

10 Sasaki R, Yasuda K, Abe E, et al. Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy. Int J Radiat Oncol Biol Phys. 2012;82(2):626-34. http://doi.org/10.1016/j.ijrobp.2010.11.037. PMid:21277117.

11 Hasle H, Clemmensen IH, Mikkelsen M. Risks of leukemia and solid tumours in individuals with Down’s syndrome. Lancet. 2000;355(9199):165-9. http://doi.org/10.1016/S0140-6736(99)05264-2. PMid:10675114.

12 Rabin KR, Whitlock JA. Malignancy in children with trisomy 21. Oncologist. 2009;14(2):164-73. http://doi.org/10.1634/theoncologist.2008-0217. PMid:19176633.

13 Hseu AF, Spencer GP, Jo S, Clark R, Nuss RC. Laryngeal pathologies in dysphonic children with Down Syndrome. Int J Pediatr Otorhinolaryngol. 2022;157:111118. http://doi.org/10.1016/j.ijporl.2022.111118. PMid:35405441.

14 Gholizadeh N, Mehdipour M, Rohani B, Esmaeili V. Extramedullary plasmacytoma of the oral cavity in a young man: a case report. J Dent. 2016;17(2):155-8. PMid:27284562.

15 Corvo MA, Granato L, Ikeda F, de Próspero JD. Extramedullary nasal plasmacytoma: literature review and a rare case report. Int Arch Otorhinolaryngol. 2013;17(2):213-7. PMid:25992016.

16 Pinto JA, Sônego TB, Artico MS, Leal CF, Bellotto S. Extramedullary plasmacytoma of the larynx. Int Arch Otorhinolaryngol. 2012;16(3):410-3. http://doi.org/10.7162/S1809-97772012000300019. PMid:25991967.

17 Weber DM. Solitary bone and extramedullary plasmacytoma. Hematology. 2005;2005(1):373-6. http://doi.org/10.1182/asheducation-2005.1.373. PMid:16304406.

18 Vong S, Navarro SM, Darrow M, Aminololama-Shakeri S. Extramedullary Plasmacytoma of the breast in a patient with Multiple Myeloma. J Radiol Case Rep. 2020;14(12):14-23. http://doi.org/10.3941/jrcr.v14i12.4110. PMid:33717400.

19 Bachar G, Goldstein D, Brown D, et al. Solitary extramedullary plasmacytoma of the head and neck--long-term outcome analysis of 68 cases. Head Neck. 2008;30(8):1012-9. http://doi.org/10.1002/hed.20821. PMid:18327783.
 


Submitted date:
04/26/2024

Accepted date:
05/25/2024

Publication date:
08/02/2024

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