Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2021.398
Autopsy and Case Reports
Clinical Case Report

Benign glandular schwannoma

Khaldoon Aljerian

Downloads: 0
Views: 60

Abstract

We report a case of a benign glandular schwannoma in a 63-year-old male who presented with a solitary subcutaneous mass on the left knee, with no previous history of neurofibromatosis type 1. This histological subtype is rare, with only 38 cases reported in the literature. Some of the glands found in this patient resembled sweat glands. These lining stromal spindle cells were positive for S-100 but negative for EMA. S100 was faintly staining the glandular elements. All the glands in the tumor were positive for EMA, particularly at the luminal borders. They were also positive for pancytokeratin. The cystic areas variably show intraluminal, foamy, and hemosiderin-laden macrophages. The different glands expressed two patterns. Some of these were reactive for CK7 and low molecular weight keratin. Immunohistochemical workup is mandatory to assess the neoplastic nature of this glandular component.

Keywords

Glandular schwannoma, immunohistochemistry, neurilemmoma, sweat glands neplasms

References

1 Chuang ST, Wang HL. An unusual case of glandular schwannoma. Hum Pathol. 2007;38(4):673-7. http://dx.doi.org/10.1016/j.humpath.2006.10.016. PMid:17258283.

2 Woodruff JM, Christensen WN. Glandular peripheral nerve sheath tumors. Cancer. 1993;72(12):3618-28. http://dx.doi.org/10.1002/1097-0142(19931215)72:12<3618::AID-CNCR2820721212>3.0.CO;2-#. PMid:8252477.

3 Uri AK, Witzleben CL, Raney RB. Electron microscopy of glandular schwannoma. Cancer. 1984;53(3):493-7. http://dx.doi.org/10.1002/1097-0142(19840201)53:3<493::AID-CNCR2820530320>3.0.CO;2-M. PMid:6692256.

4 Kim YC, Park HJ, Cinn YW, Vandersteen DP. Benign glandular schwannoma. Br J Dermatol. 2001;145(5):834-7. http://dx.doi.org/10.1046/j.1365-2133.2001.04476.x. PMid:11736913.

5 Holliday AC, Mazloom SE, Coman GC, Kolodney MS, Chavan RN, Grider DJ. Benign glandular schwannoma with ancient change. Am J Dermatopathol. 2017;39(4):300-3. http://dx.doi.org/10.1097/DAD.0000000000000739. PMid:27805920.

6 Ferry JA, Dickersin GR. Pseudoglandular schwannoma. Am J Clin Pathol. 1988;89(4):546-52. http://dx.doi.org/10.1093/ajcp/89.4.546. PMid:3354508.

7 Deng A, Petrali J, Jaffe D, Sina B, Gaspari A. Benign cutaneous pseudoglandular schwannoma: a case report. Am J Dermatopathol. 2005;27(5):432-5. http://dx.doi.org/10.1097/01.dad.0000175534.73110.4e. PMid:16148415.

8 Ide F, Obara K, Mishima K, Saito I. Intraparotid pseudoglandular schwannoma. J Oral Pathol Med. 2006;35(6):379-81. http://dx.doi.org/10.1111/j.1600-0714.2006.00413.x. PMid:16762020.

9 Lisle A, Jokinen C, Argenyi Z. Cutaneous pseudoglandular schwannoma: a case report of an unusual histopathologic variant. Am J Dermatopathol. 2011;33(5):e63-5. http://dx.doi.org/10.1097/DAD.0b013e3181f86879. PMid:21478728.

10 Ud Din N, Ahmad Z, Ahmed A. Schwannomas with pseudoglandular elements: clinicopathologic study of 61 cases. Ann Diagn Pathol. 2016;20:24-8. http://dx.doi.org/10.1016/j.anndiagpath.2015.10.009. PMid:26626208.

11 Christensen WN, Strong EW, Bains MS, Woodruff JM. Neuroendocrine differentiation in the glandular peripheral nerve sheath tumor. Pathologic distinction from the biphasic synovial sarcoma with glands. Am J Surg Pathol. 1988;12(6):417-26. http://dx.doi.org/10.1097/00000478-198806000-00001. PMid:2837100.

12 Joshi D, Gangane N, Kishore S, Vagha S. Unusual histological presentation in neurofibromas: two case reports. Cases J. 2008;1(1):188. http://dx.doi.org/10.1186/1757-1626-1-188. PMid:18823533.

13 Kusumi T, Tanaka M, Kurita T, et al. Non-neoplastic glandular structures in a benign peripheral nerve sheath tumor. Pathol Int. 2001;51(8):633-7. http://dx.doi.org/10.1046/j.1440-1827.2001.01244.x. PMid:11564219.

14 AlAli BM, Amr SS. Malignant glandular triton tumor arising in the radial nerve with prolonged survival: a case report and review of the literature. Case Rep Pathol. 2021;2021:4614185. http://dx.doi.org/10.1155/2021/4614185. PMid:33791136.

15 Callagy G, Thornton J, Rawluk D, Farrell MA. Benign glandular peripheral nerve sheath tumor of the seventh and eighth cranial nerve complex. Clin Neuropathol. 2000;19(2):104-7. PMid:10749291.

16 Schaefer IM, Agaimy A, Fletcher CDM, Hornick JL. Claudin-4 expression distinguishes SWI/SNF complex-deficient undifferentiated carcinomas from sarcomas. Mod Pathol. 2017;30(4):539-48. http://dx.doi.org/10.1038/modpathol.2016.230. PMid:28084340.

17 Saggini A, Di Prete M, D’Amico F, Lora V, Orlandi A. Glandular Schwannoma: an uncommon variant of schwannoma with controversial histogenesis. Dermatopathology (Basel). 2019;6(4):206-12. http://dx.doi.org/10.1159/000503599. PMid:31828061.
 


Submitted date:
08/12/2022

Accepted date:
08/30/2022

Publication date:
09/15/2022

63231465a9539576352e0733 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections