Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2021.378
Autopsy and Case Reports
Clinical Case Report and Review

Ulcerative colitis after SARS-CoV-2 infection

Sofia Kartsoli; Spyridon Vrakas; Dimitrios Kalomoiris; Kassiani Manoloudaki; Vasileios Xourgias

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Abstract

Although severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) affects mainly the respiratory system, the gastrointestinal tract is also considered a site of viral activity. We hereby present the case of a 74-year-old male patient with the diagnosis of new-onset ulcerative colitis. One month earlier, the patient presented fever, running nose, and diarrhea and was tested positive for SARS-CoV-2. Studies with COVID-19 patients revealed significant changes in gut microbiota composition and alterations in immune responses that could lead to chronic inflammation and manifestations of inflammatory bowel disease. We review additional cases of ulcerative colitis presented after SARS-CoV-2 infection and summarize the possible mechanisms that underlie the gastrointestinal abnormalities in COVID-19 patients.

Keywords

COVID-19, SARS-CoV-2, Ulcerative colitis

References

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Submitted date:
01/22/2022

Accepted date:
04/09/2022

Publication date:
04/28/2022

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