Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2021.375
Autopsy and Case Reports
Clinical Case Report and Review

Invasive cystic hypersecretory carcinoma of the breast

Srilata Chitti; Sunayana Misra; Arvind Ahuja; Nikhil Gupta; Raghav Yelamanchi

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Abstract

Cystic hypersecretory carcinoma (CHC) of the breast is a rare variant of ductal carcinoma, characterized by variably sized cysts lined by micropapillary fronds to proliferative pseudostratified columnar epithelium. It includes a spectrum of morphological features ranging from clearly benign cystic hypersecretory hyperplasia (CHH), CHH with atypia to invasive CHC. Only 20 cases of invasive CHC have been reported to date. We report a case of a 49-year-old female who presented with a palpable breast lump and nipple discharge. Gross examination showed variable-sized cysts lined by solid grey white tumors. On microscopic examination, cysts were lined by micropapillary fronds with eosinophilic colloid-like secretion with a focus of invasion. A diagnosis of invasive CHC was made. Since there are limited case reports, our understanding of its biological behavior, prognostic factors, and genetic basis is limited.

Keywords

Breast, Mammography, Breast cyst, Breast Neoplasms

References

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Submitted date:
06/05/2021

Accepted date:
03/31/2022

Publication date:
04/28/2022

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