Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2021.355
Autopsy and Case Reports
Clinical Case Report and Review

Primary retroperitoneal extraovarian granulosa cell tumor

Pragya Sharma; Vikram Singh; Niharika Mishra; Manoj Gopinath; Prashant Gupta

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Abstract

Extraovarian granulosa cell tumors (GCTs) develop from ectopic gonadal tissue situated along the embryonal route of the genital ridge. Primary retroperitoneal tumors are extremely rare, with an incidence of 02% -06% and 80-85% probability of malignancy. Only eight such case reports have been published previously. We herein, report a rare case of extraovarian retroperitoneal GCT in a 55-year-old woman who presented with intermittent left lumbar region pain of one-year duration. She had a history of hysterectomy and bilateral salpingo-oophorectomy 8 years ago for uterine leiomyoma. Laparotomy revealed a retroperitoneal mass measuring 8cm x 10cm x 20cm in size, solid cystic with areas of necrosis and hemorrhage. The gross features, classical histopathology, and positive immunostaining of the retroperitoneal mass with inhibin, calretinin, PR, WT1 and immunonegativity for EMA were characteristic of adult-type GCT. Excluding any previous history of primary ovarian GCT in this patient, a de-novo retroperitoneal diagnosis was established.

Keywords

Granulosa cell tumor, immunohistochemistry, inhibins

References

1 Chen, Y. C., Chang, L. C., & Soong, R. S. (2012). A late recurring and easily forgotten tumor: ovarian granulosa cell tumor. World Journal of Surgical Oncology, 10(1), 85. http://dx.doi.org/10.1186/1477-7819-10-85. PMid:22591557.

2 Chiriac D, Todorut FM, Fogarassy A, Corpade A, Grigoras D. P31.04: Primary retroperitoneal granulosa cell tumor: a case report. Ultrasound Obstet Gynecol. 2014;44(S1 Suppl):365. http://dx.doi.org/10.1002/uog.14597.

3 Paul PC, Chakraborty J, Chakrabarti S, Chattopadhyay B. Extraovarian granulosa cell tumor. Indian J Pathol Microbiol. 2009;52(2):231-3. http://dx.doi.org/10.4103/0377-4929.48928. PMid:19332923.

4 Vassallo MC, Collict M, Buhagiar T, Formosa M. Retroperitoneal granulosa cell tumor. J Case Rep Images Obstet Gynecol. 2019;5:100045Z08MV2019.

5 Swain SK, Ahmed A, Mohan AT, Munikrishnan V. Primary extraovarian Granulosa Cell Tumor (GCT) of Omentum: a rare occurrence. Trop Gastroenterol. 2020;41(2):48-50.

6 Barbosa LCR, Campos FSM, Archangelo SDCV, Francisco AMC. Extraovarian Granulosa cell tumor of fallopian tube - a case report. J Minim Invasive Gynecol. 2013;20(6):S159. http://dx.doi.org/10.1016/j.jmig.2013.08.536.

7 Kim SH, Park HJ, Linton JA, et al. Extraovarian granulosa cell tumor. Yonsei Med J. 2001;42(3):360-3. http://dx.doi.org/10.3349/ymj.2001.42.3.360. PMid:11456406.

8 Rifki JS, Farah RH, Boussabir A, Boufettal R, Chehab F. Extraovarian granulosa cell tumor: a case report. Pan Afr Med J. 2016;23:86.

9 Medhi, P., & Dowerah, S. (2016). A rare case of Extraovarian Granulosa Cell Tumor presenting as a retroperitoneal mass. Annals Pathol Lab Med., 3(3), 154-155.

10 Vasu PP, Leelamma JP, Mohammed BA, Yesodharan J. Primary granulosa cell tumor of retroperitoneal origin: a rare presentation with emphasis on cytomorphology. J Cytol. 2016;33(1):52-4. http://dx.doi.org/10.4103/0970-9371.175527. PMid:27011446.

11 Al-Shraideh, Y., Mahfooz, A. B., Moazin, M., Aslam, M., Alhazmi, A., & Alshakweer, W. (2012). Primary retroperitoneal Granulosa Cell tumor. UroToday Int., 5(6), 66.

12 Zaloudek CJ, Staats PN, Mooney EE, et al. Sex cord – stromal tumors – pure sex cord tumors. In: Kurman RJ, editor. WHO classification of tumors of Female Reproductive Organs. Lyon: IARC; 2014. p. 50-1.

13 Naniwadekar MR, Patil NJ. Extraovarian granulosa cell tumor of mesentery: a case report. Patholog Res Int. 2010;2010:292606. http://dx.doi.org/10.4061/2010/292606. PMid:21152176.

14 Singh A, Singh V, Bhargava M, et al. An unusual presentation of a granulosa cell tumor in broad ligament: morphological features and close differential. Trop J Path Micro. 2019;5(9):740-4. http://dx.doi.org/10.17511/jopm.2019.i09.20.

15 Hameed A, Coleman RL. Fine-needle aspiration cytology of primary granulosa cell tumor of the adrenal gland: a case report. Diagn Cytopathol. 2000;22(2):107-9. http://dx.doi.org/10.1002/(SICI)1097-0339(200002)22:2<107::AID-DC10>3.0.CO;2-1. PMid:10649522.

16 Portuesi R, Loppini A,Mancari R. Role of inhibin B in detecting recurrence of granulosa cell tumors of the ovary in postmenopausal patients. International Journal of Gynecologic Cancer. 2021;31:893-898

17 Lyubimova NV, Beyshembaev AM, Kushlinskiy DN, Zordania KI, Adamyan LV. Granulosa cell tumors of the ovary and inhibin B. Bull Exp Biol Med. 2011;150(5):635-8
 


Submitted date:
10/19/2021

Accepted date:
01/08/2022

Publication date:
02/11/2022

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