Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2021.340
Autopsy and Case Reports
Clinical Case Report

Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

Frederick Eyerer; Juli-Anne Gardner; Katherine A. Devitt

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Abstract

Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.

Keywords

Lymphoma, Mantle-Cell, Splenic Rupture, Cyclin D, Lymphoma, Malignant

References

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Submitted date:
08/19/2021

Accepted date:
10/04/2021

Publication date:
11/05/2021

61851477a95395665027a195 autopsy Articles
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