Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2021.313
Autopsy and Case Reports
Short Communication

COVID-19 associated pulmonary aspergillosis (CAPA) in a pregnant woman

Shruti Agrawal; Ravi Hari Phulware

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Abstract

Viral or bacterial co-infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported in the literature. However, the knowledge on Aspergillus co-infection among patients with coronavirus disease 2019 (COVID-19) is limited. COVID‐19‐associated pulmonary aspergillosis (CAPA) has been seen in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS), which has raised concerns about the worsening disease course of COVID-19 and increasing mortality. We describe a clinical case of CAPA infection and acute respiratory distress syndrome (ARDS) with a deathly outcome in a previously well, non-immunocompromised pregnant woman with intrauterine death of the fetus. Hence, we suggest that clinicians and pathologists keep alerting the possible occurrence of pulmonary aspergillosis in severe/critical COVID-19 patients, and aggressive investigations should be done to rule out the possibility of CAPA so that early treatment can be administrated.

Keywords

COVID-19, Pulmonary Aspergillosis, Respiratory Distress Syndrome,, Fungi, SARS-CoV-2

References

1 Koehler P, Bassetti M, Chakrabarti A, et al. Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance. Lancet Infect Dis. 2020;21(6):e149-e162.

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3 Arkel ALE, Rijpstra TA, Belderbos HNA, Wijngaarden P, Verweij PE, Bentvelsen RG. COVID-19-associated Pulmonary Aspergillosis. Am J Respir Crit Care Med. 2020;202(1):132-5. http://dx.doi.org/10.1164/rccm.202004-1038LE. PMid:32396381.

4 Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with Coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis. 2020;71(15):762-8. http://dx.doi.org/10.1093/cid/ciaa248. PMid:32161940.

5 Blot SI, Taccone FS, Abeele AM, et al. A clinical algorithm to diagnose invasive pulmonary aspergillosis in critically ill patients. Am J Respir Crit Care Med. 2012;186(1):56-64. http://dx.doi.org/10.1164/rccm.201111-1978OC. PMid:22517788.
 


Submitted date:
06/05/2021

Accepted date:
06/28/2021

Publication date:
08/20/2021

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