Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report

HTLV-1 infection in acute t- lymphocytic leukemia/lymphoma

Mohammad Barouqa; Morayma Reyes Gil; Radhika Sekhri; Mojisola Popoola; Juan Ding; Yanhua Wang

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Adult T- lymphocyte leukemia/ lymphoma (ATLL), described by Uchiyama et al. in 1977, is a distinct neoplasia of peripheral T-lymphocytes caused by human T-cell lymphotropic virus type 1 (HTLV-1). The authors describe the case of a 75-year-old female patient who presented with fever, chills, and altered mental status. The peripheral blood morphology showed large atypical lymphocytes with multilobed nuclei and flow cytometry consistent with ATLL. The authors discuss the pathophysiology, differential diagnosis, and subtypes of ATLL in addition to the diagnostic approach using flow cytometry when bone marrow biopsy is not available and modalities of treatment.


Human T-lymphotropic virus 1, Leukemia, Lymphoid, Leukemia-Lymphoma, Adult T-Cell


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