The vasa vasorum of the large pulmonary vessels are involved in COVID-19
Hubert Daisley Jr; Arlene Rampersad; Martina Daisley; Amit Ramdin; Oneka Acco; Farhaana Narinesingh; Ornella Humphrey; Errol James
In our manuscript “
The significance of these sites means that both, the alveolar microcirculation and the vasa vasorum of the large pulmonary vessels are involved in the thrombotic processes in COVID-19. The latter thrombotic site would further implicate COVID-19 as a disease of the microcirculation. Boyle and Haverich
As the world is grappling with the SARS-COV-2 pandemic, it is essential to understand the pathogenesis of COVID-19 to formulate therapeutic options. It may be that the lung is a secondary partner in COVID-19 and the pathogenesis of this disease begins in the nasopharynx,
1 Daisley H Jr, Rampersad A, Daisley M, et al. COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19? Autops Case Rep. 2021;11:e2021262.
2 Gössl M, Rosol M, Malyar NM, et al. Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries. Anat Rec A Discov Mol Cell Evol Biol. 2003;272(2):526-37.
3 Boyle EC, Haverich A. Microvasculature dysfunction as the common thread between atherosclerosis, Kawasaki disease, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated multi-system inflammatory syndrome in children. Eur J Cardiothorac Surg. 2020;58(6):1109-10.
4 Gallo O, Locatello LG, Mazzoni A, Novelli L, Annunziato F. The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection. Mucosal Immunol. 2021;14(2):305-16.
5 Loo J, Spittle DA, Newnham M. COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms. Thorax. 2021;76(4):412-20.
6 Tiwari NR, Phatak S, Sharma VR, Agarwal SK. COVID-19 and thrombotic microangiopathies. Thromb Res. 2021;202:191-8.