Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2021.294
Autopsy and Case Reports
Clinical Case Report

Pulmonary sarcoidosis with arterial involvement

Adriane Souza da Paz; João Carlos Coelho; Bartira Melo; Ana Luísa Pedreira; Mittermayer Barreto Santiago

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Abstract

Necrotizing sarcoid granulomatosis (NSG) is a rare and under-recognized cause of granulomatous disease, described as a variant of typical nodular sarcoidosis. It can be asymptomatic when the patient has a single pulmonary nodule or may be accompanied by cough, fever, and dyspnea, or even symptoms due to the involvement of other organs such as the eyes, liver, and central nervous system. The histopathological analysis is essential for the differential diagnosis of other infectious and non-infectious causes of granuloma and to determine the appropriate treatment. NSG is characterized by the presence of a granuloma with extensive coagulative necrosis associated with the occurrence of vasculitis. We present the case of a patient diagnosed with NSG who had an unusual outcome with recurrent pulmonary thromboembolisms followed by hemodynamic instability and death.

Keywords

Granuloma, Granulomatosis with Polyangiitis, Sarcoidosis

References

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Submitted date:
06/07/2020

Accepted date:
05/16/2021

Publication date:
07/08/2021

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