Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report and Review

Primary malignant giant cell tumor of the sternum

Mohammed Imaduddin; Pavithra Ayyanar; Mahesh Sultania; Dillip Muduly; Mukund Namdev Sable; Suprava Naik; Sambit Mohanty; Madhabananda Kar

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Primary malignant giant cell tumor (PMGCT) is a diagnosis based on the presence of a high-grade sarcomatous component along with a typical benign giant cell tumor (GCT). We report the first case of PMGCT of the sternum in a 28-year-old male with painless swelling over the manubrium sterni. The differential diagnoses of PMGCT and giant cell-rich osteosarcoma were considered. Surgical resection was performed, and the reconstruction was done with a neosternum using polymethyl methacrylate and prolene mesh. At 30 months follow-up, the patient is disease-free.


Neoplasms, Giant cell tumors, Sternum


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