Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2021.277
Autopsy and Case Reports
Clinical Case Report and Review

Gangliocytic paraganglioma of the spine

Shubha Lal; Ishita Pant; Sujata Chaturvedi; Pragyan Sarma

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Abstract

Paragangliomas are rare, encapsulated, benign neuroendocrine tumors that can arise from the adrenal medulla or extra-adrenal paraganglia. Extra-adrenal paragangliomas may develop a gangliocytic component with ganglion cells (Gangliocytic paragangliomas). Nearly 25%of cauda equina paragangliomas are gangliocytic paragangliomas. Here, we describe the case of a 35-year-old male who presented with weakness of both lower limbs over the last two months. Radiological findings were suggestive of myxopapillary ependymoma. However, the histopathological examination revealed a tumor with cells arranged in sheets, papillae, lobules, and around vessels forming pseudo rosettes. Ganglion cells were seen in small groups and, also singly. Tumor cells were immunopositive for chromogranin, synaptophysin, and S-100. Ganglion cells were immunopositive for synaptophysin, NSE, and NFP. A final histological diagnosis of Gangliocytic paraganglioma (WHO grade I) was made. To date, only nine gangliocytic paraganglioma cases have been previously reported, and to the best of our knowledge, this is the largest gangliocytic paraganglioma.

Keywords

gangliocytic paraganglioma, spine

References

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Submitted date:
11/11/2020

Accepted date:
03/15/2021

Publication date:
05/06/2021

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