Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2021.270
Autopsy and Case Reports
Clinical Case Report and Review

Parathyroid hemangioma

Odille Mejia; Hisham F. Bahmad; Kei Shing Oh; Juan C. Paramo; Robert Poppiti

Downloads: 1
Views: 1309

Abstract

Background: Hemangiomas are benign neoplasms of capillary proliferation that arise from a developmental anomaly where angioblastic mesenchyme fails to form canals. Most hemangiomas arise in the head and neck region, either superficially in the skin or deeper within endocrine organs such as the parotid gland. Parathyroid hemangiomas, however, are extremely rare, with only five cases previously reported in the literature.

Case presentation: Herein, we present a case of a 68-year-old man with a hemangioma almost completely replacing the right upper parathyroid gland, grossly measuring 1.3 × 1.3 × 1.2 cm and weighing 700 mg, associated with primary hyperparathyroidism.

Conclusions: Parathyroid gland enlargement due to vascular neoplasms such as hemangiomas can mimic, both clinically and radiographically, hyperplasias and/or adenomas. Surgeons need to be aware of the presence of this entity and should consider it in the differential diagnosis of hyperparathyroidism or parathyroid gland enlargement.

Keywords

Parathyroid Neoplasms, Hemangioma, Parathyroid Diseases, Adenoma, Case Reports

References

1 Wassef M, Blei F, Adams D, et al. Vascular anomalies classification: recommendations from the international society for the study of vascular anomalies. Pediatrics. 2015;136(1):e203-14. http://dx.doi.org/10.1542/peds.2014-3673. PMid:26055853.

2 Brahmbhatt AN, Skalski KA, Bhatt AA. Vascular lesions of the head and neck: an update on classification and imaging review. Insights Imaging. 2020;11(1):19. http://dx.doi.org/10.1186/s13244-019-0818-3. PMid:32034537.

3 Nair SC. Vascular anomalies of the head and neck region. J Maxillofac Oral Surg. 2018;17(1):1-12. http://dx.doi.org/10.1007/s12663-017-1063-2. PMid:29382987.

4 Fowell C, Verea Linares C, Jones R, Nishikawa H, Monaghan A. Venous malformations of the head and neck: current concepts in management. Br J Oral Maxillofac Surg. 2017;55(1):3-9. http://dx.doi.org/10.1016/j.bjoms.2016.10.023. PMid:27894790.

5 Dilsiz A, Aydin T, Gursan N. Capillary hemangioma as a rare benign tumor of the oral cavity: a case report. Cases J. 2009;2(1):8622. http://dx.doi.org/10.4076/1757-1626-2-8622. PMid:20181211.

6 Kumar R, Gupta R, Khullar S, Dasan B, Malhotra A. Thyroid hemangioma: a case report with a review of the literature. Clin Nucl Med. 2000;25(10):769-71. http://dx.doi.org/10.1097/00003072-200010000-00003. PMid:11043713.

7 Shpitzer T, Noyek AM, Witterick I, et al. Noncutaneous cavernous hemangiomas of the head and neck. Am J Otolaryngol. 1997;18(6):367-74. http://dx.doi.org/10.1016/S0196-0709(97)90055-7. PMid:9395011.

8 Kadriyan H, Sulaksana MA, Yudhanto D, et al. Subcutaneous hemangioma on nasal dorsum: a case report. J Med Case Reports. 2020;14(1):128. http://dx.doi.org/10.1186/s13256-020-02443-4. PMid:32787966.

9 Kawakami M, Hayashi I, Yoshimura K, Ichihara K, Nishikawa S, Ichihara T. Adult giant hemangioma of the larynx: a case report. Auris Nasus Larynx. 2006;33(4):479-82. http://dx.doi.org/10.1016/j.anl.2006.05.010. PMid:16934420.

10 Merino MJ, Chuaqui R, Fernandez P. Parathyroid hemangioma: a report of two cases. Endocr Pathol. 1996;7(4):319-22. http://dx.doi.org/10.1007/BF02739839. PMid:12114803.

11 Nguyen PL, Poetker DM, Zambrano E. Parathyroid hemangioma: a case report in proof of its existence. Endocr Pathol. 2011;22(1):53-6. http://dx.doi.org/10.1007/s12022-011-9150-2. PMid:21286857.

12 Svec A, Bury Y. Haemangioma of the parathyroid gland. does it really exist? Pathol Oncol Res. 2010;16(3):443-6. http://dx.doi.org/10.1007/s12253-009-9236-z. PMid:20063187.

13 Snyder V, Bayrak S, Woodroof J, Kakarala K. A parathyroid hemangioma of the retropharynx. JAMA Otolaryngol Head Neck Surg. 2018;144(12):1181-3. http://dx.doi.org/10.1001/jamaoto.2018.2248. PMid:30242327.

14 Yeh R, Tay Y-KD, Dercle L, Bandeira L, Parekh MR, Bilezikian JP. A simple formula to estimate parathyroid weight on 4D-CT, predict pathologic weight, and diagnose parathyroid adenoma in patients with primary hyperparathyroidism. AJNR Am J Neuroradiol. 2020;41(9):1690-7. http://dx.doi.org/10.3174/ajnr.A6687. PMid:32816774.

15 Webb SM, Wägner AM. Vascular anatomy of the endocrine organs. In: Lanzer P, editor. Panvascular medicine. Berlin: Springer ; 2015. p. 4593-6. http://dx.doi.org/10.1007/978-3-642-37078-6_167.

16 Wang JF, Milosveski V, Schramek C, Fong GH, Becks GP, Hill DJ. Presence and possible role of vascular endothelial growth factor in thyroid cell growth and function. J Endocrinol. 1998;157(1):5-12. http://dx.doi.org/10.1677/joe.0.1570005. PMid:9614352.

17 George A, Mani V, Noufal A. Update on the classification of hemangioma. J Oral Maxillofac Pathol. 2014;18(4, Suppl 1):S117-20. http://dx.doi.org/10.4103/0973-029X.141321. PMid:25364160.

18 Donnelly LF, Adams DM, Bisset GS 3rd. Vascular malformations and hemangiomas: a practical approach in a multidisciplinary clinic. AJR Am J Roentgenol. 2000;174(3):597-608. http://dx.doi.org/10.2214/ajr.174.3.1740597. PMid:10701595.

19 Hovi SI, Kholová I. Vascular proliferation of the thyroid: potential histopathological pitfalls as a consequence of fine needle aspiration. Acta Cytol. 2017;61(3):179-86. http://dx.doi.org/10.1159/000476024. PMid:28514786.

20 Miao J, Chen S, Li Y, Fu L, Li H. A primary cavernous hemangioma of the thyroid gland: a case report and literature review. Medicine. 2017;96(49):e8651. http://dx.doi.org/10.1097/MD.0000000000008651. PMid:29245224.

21 Norman J, Politz D, Browarsky I. Diagnostic aspiration of parathyroid adenomas causes severe fibrosis complicating surgery and final histologic diagnosis. Thyroid. 2007;17(12):1251-5. http://dx.doi.org/10.1089/thy.2007.0081. PMid:17887929.
 


Submitted date:
02/06/2021

Accepted date:
02/21/2021

Publication date:
05/25/2021

60ad35caa953952f000ce016 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections