Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report

Congenital medulloblastoma presented in the neonatal period

Patricio García-Espinosa; Max Molina-Ayala; Edgar Botello-Hernández; Estefania Villareal-Garza; Álvaro Barbosa-Quintana

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Congenital medulloblastoma is a rare brain tumor that appears in less than 1% of pediatric patients. Congenital medulloblastoma has a poor prognosis and should be suspected in patients with clinical manifestations of hyporeactivity, slow suction reflexes, and the presence of hydrocephalus. Herein we present the case of a 12-day-old female newborn who developed non-communicative hydrocephalus, hyporeactivity, and hyporeflexia. Magnetic resonance imaging of her brain showed a heterogeneous and cystic mass on the posterior cranial fossa. A suboccipital craniotomy was performed. The histopathologic analysis reported a congenital medulloblastoma. She remained in hospital until her death at 112 days old. This is one of the first case reports with clinical-radiological and pathological documentation. Awareness of this diagnosis can allow prenatal intervention, rendering a better prognosis. This case report exemplifies the importance of good prenatal follow-up.


Brain Neoplasms, Medulloblastoma, Pathology, Radiology, Case Reports


1 Korostyshevskaya A, Savelov A, Papusha L, Druy AE, Yarnykh VL. Congenital medulloblastoma: fetal and postnatal longitudinal observation with quantitative MRI. Clin Imaging. 2018;52:172-6. PMid:30096555.

2 Buetow PC, Smirniotopoulos JG, Done S. Congenital brain tumors: a review of 45 cases. AJR Am J Roentgenol. 1990;155(3):587-93. PMid:2167004.

3 Gilbertson RJ. Medulloblastoma: signaling a change in treatment. Lancet Oncol. 2004;5(4):209-18. PMid:15050952.

4 Wakai S, Arai T, Nagai M. Congenital brain tumors. Surg Neurol. 1984;21(6):597-609. PMid:6372141.

5 Sugimoto M, Kurishima C, Masutani S, Tamura M, Senzaki H. Congenital brain tumor within the first 2 months of life. Pediatr Neonatol. 2015;56(6):369-75. PMid:26044848.

6 Alamo L, Beck-Popovic M, Gudinchet F, Meuli R. Congenital tumors: imaging when life just begins. Insights Imaging. 2011;2(3):297-308. PMid:22347954.

7 Rossi A, Caracciolo V, Russo G, Reiss K, Giordano A. Medulloblastoma: from molecular pathology to therapy. Clin Cancer Res. 2008;14(4):971-6. PMid:18281528.

8 Bunin GR, Kushi LH, Gallagher PR, Rorke-Adams LB, McBride ML, Cnaan A. Maternal diet during pregnancy and its association with medulloblastoma in children: a children’s oncology group study (United States). Cancer Causes Control. 2005;16(7):877-91. PMid:16132798.

9 Bunin GR, Gallagher PR, Rorke-Adams LB, Robison LL, Cnaan A. Maternal supplement, micronutrient, and cured meat intake during pregnancy and risk of medulloblastoma during childhood: a children’s oncology group study. Cancer Epidemiol Biomarkers Prev. 2006;15(9):1660-7. PMid:16985028.

10 Baryawno N, Rahbar A, Wolmer-Solberg N, et al. Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. J Clin Invest. 2011;121(10):4043-55. PMid:21946257.

11 Krynska B, Del Valle L, Croul S, et al. Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas. Proc Natl Acad Sci USA. 1999;96(20):11519-24. PMid:10500209.

12 Rincón V, Corredor A, Martínez-Gutierrez M, Castellanos JE. Fluorometric cell-ELISA for quantifying rabies infection and heparin inhibition. J Virol Methods. 2005;127(1):33-9. PMid:15893563.

13 Smoll NR, Drummond KJ. The incidence of medulloblastomas and primitive neuroectodermal tumours in adults and children. J Clin Neurosci. 2012;19(11):1541-4. PMid:22981874.

14 Ermis B, Aydemir C, Taspinar O, Cagavi F, Bahadir B, Ozdemir H. Congenital medulloblastoma. Arch Dis Child Fetal Neonatal Ed. 2006;91(5):F373. PMid:16923937.

15 Di Rocco C, Ceddia A, Iannelli A. Intracranial tumours in the first year of life: a report on 51 cases. Acta Neurochir. 1993;123(1-2):14-24. PMid:8213273.

16 Farwell JR, Dohrmann GJ, Flannery JT. Intracranial neoplasms in infants. Arch Neurol. 1978;35(8):533-7. PMid:666614.

17 Amacher AL, Torres QU, Rittenhouse S. Congenital medulloblastoma: an inquiry into origins. Childs Nerv Syst. 1986;2(5):262-5. PMid:3791286.

18 Yang J, Kim S-K, Wang K-C, Kim K-H, Park S-H, Phi JH. A boy with a congenital cerebellar mass. Childs Nerv Syst. 2021;37(3):983-7. PMid:32613423.

19 Evans G, Burnell L, Campbell R, Gattamaneni HR, Birch J. Congenital anomalies and genetic syndromes in 173 cases of medulloblastoma. Med Pediatr Oncol. 1993;21(6):433-4. PMid:8515724.

20 Mayner-Tresol G, Reyna-Villasmil E. Meduloblastoma cerebeloso durante el embarazo: reporte de caso. Rev Peru Ginecol Obstet. 2019;65(2):203-8. Spanish.

21 Cu CMM, Alamillo LJ. Meduloblastoma congénito. Informe de un caso. Rev Mex Pediatr. 2012;79(1):23-7. Spanish.

22 Taboada D, Froufe A, Alonso A, Alvarez J, Muro D, Vila M. Congenital medulloblastoma: report of two cases. Pediatr Radiol. 1980;9(1):5-10. PMid:7352113.

23 Hinojosa J, Esparza J, Muñoz MJ, Muñoz A. Tumores cerebrales congénitos: presentación de nueve casos y revisión de la literatura. Neurocirugia. 2003;14(1):33-40. PMid:12655382.

24 Jellinger K, Sunder-Plassmann M. Connatal intracranial tumors. Neuropediatrie. 1973;4(1):46-63. PMid:4739778.

25 Kayama T, Yoshimoto T, Shimizu H, Sakurai Y. Neonatal medulloblastoma. J Neurooncol. 1993;15(2):157-63. PMid:8509820.

26 Gilbertson RJ, Ellison DW. The origins of medulloblastoma subtypes. Annu Rev Pathol. 2008;3(1):341-65. PMid:18039127.

27 Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131(6):803-20. PMid:27157931.

28 Viaene AN, Pu C, Perry A, Li MM, Luo M, Santi M. Congenital tumors of the central nervous system: an institutional review of 64 cases with emphasis on tumors with unique histologic and molecular characteristics. Brain Pathol. 2021;31(1):45-60. PMid:32681571.

29 Dhall G. Medulloblastoma. J Child Neurol. 2009;24(11):1418-30. PMid:19841429.

30 Northcott PA, Korshunov A, Pfister SM, Taylor MD. The clinical implications of medulloblastoma subgroups. Nat Rev Neurol. 2012;8(6):340-51. PMid:22565209.

31 Millard NE, De Braganca KC. Medulloblastoma. J Child Neurol. 2016;31(12):1341-53. PMid:26336203.

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