Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2020.231
Autopsy and Case Reports
Autopsy Case Report and Review

ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature

Kaniyappan Nambiyar; Kirti Gupta; Uma Debi; Saroj Kant Sinha; Rakesh Kochhar

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Abstract

ABSTRACT: Cardiac lymphoma is a rare entity. In this setting, the secondary involvement of the heart is far more frequent than the primary cardiac lymphoma. Herein, we present an autopsy case of a disseminated anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma with a dominant mediastinal involvement. Extensive cardiac infiltration with the near replacement of the myocardial wall by the neoplastic cells was observed. A total of nine isolated case reports of anaplastic large cell lymphoma with cardiac involvement were found in the English-language literature, and a widespread cardiac and thymic infiltration by the systemic ALK-positive anaplastic large cell lymphoma has not been documented. An incidental regenerative nodule was also identified in the liver. The patient died of pulmonary thromboembolism and cardiac arrest.

Keywords

Lymphoma, Large-cell, Anaplastic, Anaplastic lymphoma kinase, Heart, Thymus Gland, Thromboembolism

References

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Submitted date:
05/26/2020

Accepted date:
09/19/2020

Publication date:
01/28/2021

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