Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report and Review

Ossifying fibromyxoid tumor of the oral cavity: rare case report and long-term follow-up

Maria Eduarda Pérez-de-Oliveira; Thayná Melo de Lima Morais; Márcio Ajudarte Lopes; Oslei Paes de Almeida; Willie F. P. van Heerden; Pablo Agustin Vargas

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ABSTRACT: Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal soft tissue benign neoplasm with an uncertain line of differentiation, which arises most frequently in extremities. The head and neck region involvement is uncommon, with only ten intraoral cases published in the English-language literature. One additional case of OFMT is reported here, including a literature review of intraoral reported cases. A 45-year-old female patient presented a painless nodule involving the buccal mucosa of approximately two years duration, measuring nearly 1.3 cm in maximum diameter. The main histopathological features include ovoid to round cells embedded in a fibromyxoid matrix with a perpheral shell of lamellar bone. Immunohistochemically, the tumor showed immunoreactivity for vimentin and S100. No recurrence has been detected after 7 years of follow-up.


head and neck neoplasms, soft tissue neoplasms, mouth


1 Miettinen M, Finnell V, Fetsch JF. Ossifying fibromyxoid tumor of soft parts – a clinicopathologic and immunohistochemical study of 104 cases with long-term follow-up and a critical review of the literature. Am J Surg Pathol. 2008;32(7):996-1005. PMid:18469710.

2 Graham RP, Dry S, Li X, et al. Ossifying fibromyxoid tumor of soft parts: a clinicopathologic, proteomic, and genomic study. Am J Surg Pathol. 2011;35(11):1615-25. PMid:21997683.

3 Schneider N, Fisher C, Thway K. Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis. Ann Diagn Pathol. 2016;20:52-8. PMid:26732302.

4 Enzinger FM, Weiss SW, Liang CY. Ossifying fibromyxoid tumor of soft parts. A clinicopathological analysis of 59 cases. Am J Surg Pathol. 1989;13(10):817-27. PMid:2476942.

5 Dantey K, Schoedel K, Yergiyev O, McGough R, Palekar A, Rao UNM. Ossifying fibromyxoid tumor: a study of 6 cases of atypical and malignant variants. Hum Pathol. 2017;60:174-9. PMid:27816723.

6 Atanaskova Mesinkovska N, Buehler D, McClain CM, Rubin BP, Goldblum JR, Billings SD. Ossifying fibromyxoid tumor: a clinicopathologic analysis of 26 subcutaneous tumors with emphasis on differential diagnosis and prognostic factors. J Cutan Pathol. 2015;42(9):622-31. PMid:25950586.

7 Schofield JB, Krausz T, Stamp GW, Fletcher CD, Fisher C, Azzopardi JG. Ossifying fibromyxoid tumour of soft parts: immunohistochemical and ultrastructural analysis. Histopathology. 1993;22(2):101-12. PMid:8454256.

8 Williams SB, Ellis GL, Meis JM, Heffner DK. Ossifying fibromyxoid tumour (of soft parts) of the head and neck: a clinicopathological an immunohistochemical study of nine cases. J Laryngol Otol. 1993;107(1):75-80. PMid:8445324.

9 Mollaoglu N, Tokman B, Kahraman S, Cetiner S, Yucetas S, Uluoglu O. An unusual presentation of ossifying fibromyxoid tumor of the mandible: a case report. J Clin Pediatr Dent. 2007;31(2):136-8. PMid:17315811.

10 Sharif MA, Mushtaq S, Mamoon N, Khadim MT. Ossifying fibromyxoid tumor of oral cavity. J Coll Physicians Surg Pak. 2008;18(3):181-2. PMid:18460251.

11 Nonaka CF, Pacheco DF, Nunes RP, Freitas RA, Miguel MC. Ossifying fibromyxoid tumor in the mandibular gingiva: case report and review of the literature. J Periodontol. 2009;80(4):687-92. PMid:19335090.

12 Ohta K, Taki M, Ogawa I, et al. Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature. Head Face Med. 2013;9(1):16. PMid:23800162.

13 Titsinides S, Nikitakis NG, Tasoulas J, Daskalopoulos A, Goutzanis L, Sklavounou A. Ossifying fibromyxoid tumor of the retromolar trigone: a case report and systematic review of the literature. Int J Surg Pathol. 2017;25(6):526-32. PMid:28436288.

14 Fregnani ER, Pires FR, Falzoni R, Lopes MA, Vargas PA. Lipomas of the oral cavity: clinical findings, histological classification and proliferative activity of 46 cases. Int J Oral Maxillofac Surg. 2003;32(1):49-53. PMid:12653233.

15 Pérez-de-Oliveira ME, Leonel ACLDS, de Castro JFL, Carvalho EJA, Vargas PA, Perez DEDC. Histopathological findings of intraoral pleomorphic adenomas: a retrospective study of a case series. Int J Surg Pathol. 2019;27(7):729-35. PMid:31187672.

16 Folpe AL, Weiss SW. Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variants. Am J Surg Pathol. 2003;27(4):421-31. PMid:12657926.

17 Woo VL, Angiero F, Fantasia JE. Myoepithelioma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(5):581-9. PMid:15829881.

18 Allen CM. The ectomesenchymal chondromyxoid tumor: a review. Oral Dis. 2008;14(5):390-5. PMid:18593455.

19 Truschnegg A, Acham S, Kqiku L, Jakse N, Beham A. Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report. Int J Oral Sci. 2018;10(1):4. PMid:29491357.

20 Sánchez-Romero C, Oliveira MEP, Castro JFL, Carvalho EJA, Almeida OP, Perez DEDC. Glomus Tumor of the Oral Cavity: Report of a Rare Case and Literature Review. Braz Dent J. 2019;30(2):185-90. PMid:30970063.

21 Tajima S, Koda K. Atypical ossifying fibromyxoid tumor unusually located in the mediastinum: report of a case showing mosaic loss of INI-1 expression. Int J Clin Exp Pathol. 2015;8(2):2139-45. PMid:25973116.

22 Hollmann TJ, Hornick JL. INI1-deficient tumors: diagnostic features and molecular genetics. Am J Surg Pathol. 2011;35(10):e47-63. PMid:21934399.

23 Rekhi B, Thorat S, Parikh G, Jambhekar NA. Malignant ossifying fibromyxoid tumors: a report of two rare cases displaying retained INI1/SMARCB1 expression. Indian J Pathol Microbiol. 2014;57(4):652-3. PMid:25308036.

24 Kondylidou-Sidira A, Kyrgidis A, Antoniades H, Antoniades K. Ossifying fibromyxoid tumor of head and neck region: case report and systematic review of literature. J Oral Maxillofac Surg. 2011;69(5):1355-60. PMid:20950910.

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