Autopsy and Case Reports
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Vasculitis with a neuromuscular presentation and associated cancer revealed by autopsy

Larry Nichols; Mathew Joseph Karivelil

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Peripheral neuropathy is common, but rarely due to vasculitis. This report is the case of a 74-year-old woman with systemic vasculitis who presented with progressive arm and leg weakness associated with numbness. Autopsy revealed a colon cancer, which may have triggered the vasculitis. This case illustrates the association between vasculitis and malignancy. The best treatment of vasculitis in patients with cancer-associated vasculitis is usually treatment of the cancer, which often yields remission of the vasculitis. This case also illustrates the difficulty of suspecting vasculitis since the symptoms and signs are nonspecific and protean. It is important not to miss a diagnosis of vasculitis. It is often life-threatening. It is treatable. The critical step in the diagnosis of vasculitis is to think of it.


Paraneoplastic Polyneuropathy, Muscular Diseases, Systemic Vasculitis, Autopsy


Nichols L.

The Larry Nichols collection. 2020 [cited 2020 Mar 23]. Available from:

Ricci L, Luigetti M, Florio L, Capone F, Di Lazzaro V. Causes of chronic neuropathies: a single-center experience.

Neurol Sci. 2019;40(8):1611-7. []. [PMID:31001716]

Doughty CT, Seyedsadjadi R. Approach to peripheral neuropathy for the primary care clinician.

Am J Med. 2018;131(9):1010-6. []. [PMID:29408540]

Gwathmey KG, Tracy JA, Dyck PJB. Peripheral nerve vasculitis: classification and disease associations.

Neurol Clin. 2019;37(2):303-33. []. [PMID:30952411]

Corral-Gudino L, González-Vázquez E, Calero-Paniagua I, et al. The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.

Rheumatol Int. 2020;40(2):303-11. []. [PMID:31385079]

Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.

Arthritis Rheum. 2013;65(1):1-11. []. [PMID:23045170]

Fain O, Hamidou M, Cacoub P, et al. Vasculitides associated with malignancies: analysis of sixty patients.

Arthritis Rheum. 2007;57(8):1473-80. []. [PMID:18050165]

Solans-Laqué R, Bosch-Gil JA, Pérez-Bocanegra C, Selva-O’Callaghan A, Simeón-Aznar CP, Vilardell-Tarres M. Paraneoplastic vasculitis in patients with solid tumors: report of 15 cases.

J Rheumatol. 2008;35(2):294-304. [PMID:18085729]

Misra DP, Naidu GSRSNK, Agarwal V, Sharma A. Vasculitis research: current trends and future perspectives.

Int J Rheum Dis. 2019;22(Suppl 1):10-20. []. [PMID:30168260]
















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