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Article / Clinical Case Report

Giant cell reparative granuloma of the nasal cavity: a rare site of presentation with review of literature

Satya Dutta; Pakesh Baishya; Vandana Raphael; Biswajit Dey; Jaya Mishra

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Giant cell reparative granuloma (GCRG) was first described in the 1950s. It is an uncommon and benign reactive tumor that is believed to occur after trauma or inflammation. It most commonly occurs in the maxilla and mandible and rarely affects the nasal cavity. It is often seen in children and during the second to third decades of life, predominantly seen among females. Histopathologically, GCRG shows many osteoclast-like multinucleated giant cells scattered in a background of mononuclear stromal cells and spindle-shaped fibroblasts also associated with areas of hemorrhage. The distinction between GCRG and giant cell tumors (GCT)is crucial since both have a similar clinical and histological presentation, but both have different management. GCTs have malignant potential, may metastasize, and have a high rate of recurrence. Surgical excision is the mainstay therapy of GCRG to ensure a low rate of recurrence. Here we discuss two cases GCRG, both presenting as nasal mass.


Nasal Cavity, Histiocytes, Granuloma


Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibroosseous) dysplasia of the jawbones.

Oral Surg Oral Med Oral Pathol. 1953;6(1):159-75. []. [PMID:13026160]

Oda Y, Tsuneyoshi M, Shinohara N. “Solid” variant of aneurysmal bone cyst (extragnathic giant cell reparative granuloma) in the axial skeleton and long bones: a study of its morphologic spectrum and distinction from allied giant cell lesions.

Cancer. 1992;70(11):2642-9. [<2642::AID-CNCR2820701113>3.0.CO;2-#]. [PMID:1423194]

Ishinaga H, Otsu K, Mouri G, Takeuchi K. Aggressive giant cell reparative granuloma of the nasal cavity.

Case Rep Otolaryngol. 2013;2013:690194. []. [PMID:23585980]

Lingaiah J, Ganji L, Yella S, Thatikonda K. A rare case of reparative granuloma of nasal cavity.

Int J Otolaryngol Head Neck Surg. 2014;3(5):293-7. [].

Morris JM, Lane JI, Witte RJ, Thompson DM. Giant cell reparative granuloma of the nasal cavity.

AJNR Am J Neuroradiol. 2004;25(7):1263-5. [PMID:15313721]

Abdel-Rahim M. Giant cell reparative granuloma of the nasal cavity in an elderly man: a case report and literature review.

Otolaryngology Case Reports. 2018;9:23-5. [].

Seo ST, Kwon KR, Rha K-S, Kim S-H, Kim YM. Pediatric aggressive giant cell granuloma of nasal cavity.

Int J Surg Case Rep. 2015;16:67-70. []. [PMID:26433924]

Zhang Q, He Z, Wang G, Jiang H. Radiotherapy for recurrent central Giant cell granuloma: a case report.

Radiat Oncol. 2019;14(1):130. []. [PMID:31324249]

Larson AK, Amjad EH, Raulicino M. A rare giant cell lesion originating from the nasal septum.

Ann Clin Case Stud. 2018;1(1):1002.

Mohammadi S, Hassannia F. Giant cell reparative granuloma of nasal cavity, a case report.

J Craniomaxillofac Surg. 2010;38(2):145-7. []. [PMID:19501517]

















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