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Article / Clinical Case Report

Multiple osteolytic lesions due to Double-Expressor Primary non-Hodgkin Lymphoma of the Bone

Sotirios Papageorgiou; Theodoros Katsikas; Panagiota Voukelatou; Ioannis Vrettos; Asimina Papanikolaou; Anthi Bouchla; Vasiliki Pappa; Andreas Kalliakmanis

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Primary non-Hodgkin lymphoma of the bone (PLB) is a rare type of non-Hodgkin’s lymphoma (NHL) that affects the skeletal system with or without regional lymph node involvement. We present the case of a 74-year-old female patient with pain due to multifocal osteolytic lesions. The diagnosis of diffuse large B-cells (non-GCB) phenotype was made by clinical, laboratory, histopathological examination accompanied by an extensive immunohistochemical profile of one of the skeletal lesions.


Lymphoma, Non-Hodgkin, Osteolysis, Positron Emission Tomography Computed Tomography, Immunohistochemistry


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