Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2020.138
Autopsy and Case Reports
Article / Clinical Case Report

EBV-negative lymphoepithelial-like carcinoma of the lower lip

Luciana Yamamoto Almeida; Heitor Albergoni Silveira; Evânio Vilela Silva; Camila de Oliveira Barbeiro; Joaquim Augusto de Paula; Andreia Bufalino; Alfredo Ribeiro-Silva; Jorge Esquiche León

Downloads: 1
Views: 377

Abstract

Lymphoepithelial-like carcinoma (LEC) is a rare malignant neoplasm, which can be associated with Epstein-Barr virus (EBV) infection. Histologically, LEC is an undifferentiated carcinoma with an intermixed reactive lymphoplasmacytic infiltrate. LEC appears to be an uncommon tumor type of lip carcinoma. An 82-year-old white woman presented a lesion on her lower lip that developed over the last year. The lesion was characterized by ulceration with flat edges, hardened base, painful, and absence of regional lymphadenopathy. Microscopical analysis evidenced an intense inflammatory infiltrate, composed of lymphoplasmacytic cells, associated with scarce pleomorphic epithelial cells. Immunohistochemistry highlighted the LEC cells with strong expression of pan-CK AE1/AE3, EMA, p63, and p53. CD138 was also faintly positive. Ki-67 was >85%. In situ hybridization analysis did not show evidence of EBV. A diagnostic of EBV-negative LEC was made. We present an uncommon type of lip carcinoma, which can represent a diagnostic challenge for clinicians and pathologists.

Keywords

Immunohistochemistry, In Situ Hybridization, Lip diseases, Squamous Cell Carcinoma of Head and Neck

References

Rytkonen AE, Hirvikoski PP, Salo TA. Lymphoepithelial carcinoma: two case reports and a systematic review of oral and sinonasal cases. Head Neck Pathol. 2011;5(4):327-34. [https://doi.org/10.1007/s12105-011-0278-7]. [PMID:21698444]

Mahomed F, Grayson W. A rare case of lymphoepithelial carcinoma of the lip. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(5):e49-52. [https://doi.org/10.1016/j.tripleo.2008.01.016]. [PMID:18442735]

Chow TL, Chow TK, Lui YH, Sze WM, Yuen NW, Kwok SP. Lymphoepithelioma-like carcinoma of oral cavity: report of three cases and literature review. Int J Oral Maxillofac Surg. 2002;31(2):212-8. [https://doi.org/10.1054/ijom.2001.0148]. [PMID:12102423]

Bishop JA, Gaulard P, Gillison M. Lymphoepithelial carcinoma. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. editors. WHO classification of Head and Neck Tumours. Lyon: IARC Press; 2017; p. 18.

Gultekin M, Sari SY, Gunhan O, et al. Lymphoepithelial carcinoma of the lower lip: report of a case. UHOD. 2014;24(1):70-2. [https://doi.org/10.4999/uhod.12037].

Iezzoni JC, Gaffey MJ, Weiss LM. The role of Epstein-Barr virus in lymphoepithelioma-like carcinomas. Am J Clin Pathol. 1995;103(3):308-15. [https://doi.org/10.1093/ajcp/103.3.308]. [PMID:7872253]

Dubey P, Ha CS, Ang KK, et al. Nonnasopharyngeal lymphoepithelioma of the head and neck. Cancer. 1998;82(8):1556-62. [https://doi.org/10.1002/(SICI)1097-0142(19980415)82:8<1556::AID-CNCR18>3.0.CO;2-3]. [PMID:9554534]

Kurokawa H, Zhang M, Matsumoto S, et al. Reduced syndecan-1 expression is correlated with the histological grade of malignancy at the deep invasive front in oral squamous cell carcinoma. J Oral Pathol Med. 2006;35(5):301-6. [https://doi.org/10.1111/j.1600-0714.2006.00412.x]. [PMID:16630294]

Martínez A, Spencer ML, Brethauer U, Grez P, Marchesani FJ, Rojas IG. Reduction of syndecan-1 expression during lip carcinogenesis. J Oral Pathol Med. 2009;38(7):580-3. [https://doi.org/10.1111/j.1600-0714.2009.00761.x]. [PMID:19473447]

 

 

 


Publication date:
12/13/2019

5df3e4430e8825687373a14b autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections