Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2019.130
Autopsy and Case Reports
Article / Clinical Case Report

Pre-malignant signs of gastric MALT lymphoma

Renato Takayuki Hassegawa; Eduardo Koji Marchi Ogawa; Roberto El Ibrahim; Filadelfio Euclides Venco; Luis Masuo Maruta

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Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is the most common type of extra-nodal non-Hodgkin lymphoma, which mostly involves the stomach. The clinical suspicion and diagnosis are often challenging because of the lack of specific symptoms and conventional endoscopic findings. Three magnifying endoscopic signs of the gastric mucosa have been described as highly specific to the diagnosis of MALT lymphoma, such as (i) tree-like appearance of the microvessels; (ii) non-structural area; and (iii) ballooning crypt pattern. We report the case of a middle-aged woman in which these signs appeared chronologically over a period of 2 years, showing the association of the sequence of the endoscopic findings and the final histological diagnosis of gastric MALT lymphoma.

Keywords

Lymphoma, B-Cell, Marginal Zone, Endoscopy

References

Zucca E, Roggero E, Bertoni F, Cavalli F. Primary extranodal non-Hodgkin’s lymphomas. Part 1: Gastrointestinal, cutaneous and genitourinary lymphomas. Ann Oncol. 1997;19(8):727-37. [https://doi.org/10.1023/A:1008282818705]. [PMID:9332679]

Nakamura S, Matsumoto T, Iida M, Yao T, Tsuneyoshi M. Primary gastrointestinal lymphoma in Japan: a clinicopathologic analysis of 455 patients with special reference to its time trends. Cancer. 2003;97(10):2462-73. [https://doi.org/10.1002/cncr.11415]. [PMID:12733145]

Zullo A, Hassan C, Ridola L, Repici A, Manta R, Andriani A. Gastric MALT lymphoma: old and new insights. Ann Gastroenterol. 2014;27(1):27-33. [PMID:24714739]

Nonaka K, Ohata K, Matsuhashi N, et al. Is narrow‐band imaging useful for histological evaluation of gastric mucosa‐associated lymphoid tissue lymphoma after treatment? Dig Endosc. 2014;26(3):358-64. [https://doi.org/10.1111/den.12169]. [PMID:24118642]

Iwamuro M, Takata K, Kawano S, et al. Magnifying endoscopic features of follicular lymphoma involving the stomach: a report of two cases. Case Rep Gastrointest Med. 2016;2016:1-6. [https://doi.org/10.1155/2016/2082698]. [PMID:27747111]

Anagnostopoulos GK, Yao K, Kaye P, et al. High-resolution magnification endoscopy can reliably identify normal gastric mucosa, Helicobacter pylori-associated gastritis, and gastric atrophy. Endoscopy. 2007;39(3):202-7. [https://doi.org/10.1055/s-2006-945056]. [PMID:17273960]

Yao K, Oishi T, Matsui T, Yao T, Iwashita A. Novel magnified endoscopic findings of microvascular architecture in intramucosal gastric cancer. Gastrointest Endosc. 2002;56(2):279-84. [https://doi.org/10.1016/S0016-5107(02)70194-6]. [PMID:12145613]

Yao K, Anagnostopoulos G, Ragunath K. Magnifying endoscopy for diagnosing and delineating early gastric cancer. Endoscopy. 2009;41(5):462-7. [https://doi.org/10.1055/s-0029-1214594]. [PMID:19418401]

Kawamura M, Abe S, Oikawa K, et al. Topographic differences in gastric micromucosal patterns observed by magnifying endoscopy with narrow band imaging. J Gastroenterol Hepatol. 2011;26(3):477-83. [https://doi.org/10.1111/j.1440-1746.2010.06527.x]. [PMID:21155881]

Yamasaki Y, Uedo N, Kanzaki H, et al. Investigation of mucosal pattern of gastric antrum using magnifying narrow-band imaging in patients with chronic atrophic fundic gastritis. Ann Gastroenterol. 2017;30(3):302-8. [https://doi.org/10.20524/aog.2017.0134]. [PMID:28469360]

Dohi O, Yagi N, Majima A, et al. Diagnostic ability of magnifying endoscopy with blue laser imaging for early gastric cancer: a prospective study. Gastric Cancer. 2017;20(2):297-303. [https://doi.org/10.1007/s10120-016-0620-6]. [PMID:27294430]

Ono S, Kato M, Ono Y, et al. Characteristics of magnified endoscopic images of gastric extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue, including changes after treatment. Gastrointest Endosc. 2008;68(4):624-31. [https://doi.org/10.1016/j.gie.2008.02.066]. [PMID:18534580]

Ono S, Kato M, Ono Y, et al. Target biopsy using magnifying endoscopy in clinical management of gastric mucosa‐associated lymphoid tissue lymphoma. J Gastroenterol Hepatol. 2011;26(7):1133-8. [https://doi.org/10.1111/j.1440-1746.2011.06729.x]. [PMID:21443666]

Nonaka K, Ishikawa K, Arai S, et al. A case of gastric mucosa-associated lymphoid tissue lymphoma in which magnified endoscopy with narrow band imaging was useful in the diagnosis. World J Gastrointest Endosc. 2012;4(4):151-6. [https://doi.org/10.4253/wjge.v4.i4.151]. [PMID:22523617]

Zucca E, Copie-Bergman C, Ricardi U, Thieblemont C, Raderer M, Ladetto M. Gastric marginal zone lymphoma of MALT type: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24(Suppl. 6):vi144-48. [https://doi.org/10.1093/annonc/mdt343]. [PMID:24078657]

Zullo A, Hassan C, Cristofari F, Perri F, Morini S. Gastric low-grade mucosal-associated lymphoid tissue-lymphoma: helicobacter pylori and beyond. World J Gastrointest Oncol. 2010;2(4):181-6. [https://doi.org/10.4251/wjgo.v2.i4.181]. [PMID:21160595]

 

 

 


Publication date:
12/13/2019

5df3e4170e8825237173a14e autopsy Articles
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