Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2019.113
Autopsy and Case Reports
Article / Autopsy Case Report

Hypertrophic cardiomyopathy masked by pericarditis

Larry Nichols; Himara Koelmeyer

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Abstract

Hypertrophic cardiomyopathy used to be regarded as a rare untreatable cause of sudden death in young male athletes. This report is the case of a middle-aged female patient with hereditary hypertrophic cardiomyopathy masked by superimposed pericarditis and revealed by autopsy. This case report illustrates how co-morbidity can hide a crucial diagnosis. This case report also illustrates the value of autopsy disclosing a familial disease that is increasingly recognized and dramatically more treatable than a few decades ago. Sudden death due to hypertrophic cardiomyopathy has become preventable, if the diagnosis is made soon enough. The lessons for patient care from this case include the importance of not missing the diagnosis of hypertrophic cardiomyopathy in female patients.

Keywords

Hypertrophic cardiomyopathy, Pericarditis, Autopsy

References

Makavos G, Κairis C, Tselegkidi ME, et al. Hypertrophic cardiomyopathy: an updated review on diagnosis, prognosis, and treatment.

 

Heart Fail Rev. 2019;24(4):439-59. [https://doi.org/10.1007/s10741-019-09775-4]. [PMID:30852773]
 

 

McKenna WJ, Moon JC, Sulaiman A. Understanding the myocardial architecture of Hypertrophic Cardiomyopathy for clinical care.

 

 

J Am Coll Cardiol. 2019;73(20):2503-5. [https://doi.org/10.1016/j.jacc.2019.03.466]. [PMID:31118143]
 

 

Pelliccia F, Limongelli G, Autore C, Gimeno-Blanes JR, Basso C, Elliott P. Sex-related differences in cardiomyopathies.

 

 

Int J Cardiol. 2019;286:239-43. [https://doi.org/10.1016/j.ijcard.2018.10.091]. [PMID:30409740]
 

 

Sorensen LL, Pinheiro A, Dimaano VL, et al. Comparison of clinical features in blacks versus whites with Hypertrophic Cardiomyopathy.

 

 

Am J Cardiol. 2016;117(11):1815-20. [https://doi.org/10.1016/j.amjcard.2016.03.017]. [PMID:27084053]
 

 

Wells S, Rowin EJ, Bhatt V, Maron MS, Maron BJ. Association between race and clinical profile of patients referred for Hypertrophic Cardiomyopathy.

 

 

Circulation. 2018;137(18):1973-5. [https://doi.org/10.1161/CIRCULATIONAHA.117.032838]. [PMID:29712699]
 

 

Maron BJ. Clinical course and management of Hypertrophic Cardiomyopathy.

 

 

N Engl J Med. 2018;379(7):655-68. [https://doi.org/10.1056/NEJMra1710575]. [PMID:30110588]
 

 

Heitner SB, Jacoby D, Lester SJ, et al. Mavacamten treatment for obstructive Hypertrophic Cardiomyopathy: a clinical trial.

 

 

Ann Intern Med. 2019;170(11):741. [https://doi.org/10.7326/M18-3016]. [PMID:31035291]
 

 

Habib M, Hoss S, Rakowski H. Evaluation of Hypertrophic Cardiomyopathy: newer Echo and MRI Approaches.

 

 

Curr Cardiol Rep. 2019;21(8):75. [https://doi.org/10.1007/s11886-019-1173-1]. [PMID:31243594]
 

 

Miller RJH, Heidary S, Pavlovic A, et al. Defining genotype-phenotype relationships in patients with Hypertrophic Cardiomyopathy using cardiovascular magnetic resonance imaging.

 

 

PLoS One. 2019;14(6):1-22.
 

 

Bagnall RD, Ingles J, Dinger ME, et al. Whole genome sequencing improves outcomes of genetic testing in patients with Hypertrophic Cardiomyopathy.

 

 

J Am Coll Cardiol. 2018;72(4):419-29. [https://doi.org/10.1016/j.jacc.2018.04.078]. [PMID:30025578]
 

 

Captur G, Heywood WE, Coats C, et al. Identification of a multiplex biomarker panel for Hypertrophic Cardiomyopathy using quantitative proteomics and machine learning.

 

 

Mol Cell Proteomics. 2019.
 

 

Lafreniere-Roula M, Bolkier Y, Zahavich L, et al. Family screening for hypertrophic cardiomyopathy: is it time to change practical guidelines?

 

 

Eur Heart J. 2019; ehz396. [https://doi.org/10.1093/eurheartj/ehz396]. [PMID:31170284]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Publication date:
09/27/2019

5d8e4f590e8825c668140c97 autopsy Articles
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