Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2019.109
Autopsy and Case Reports
Article / Clinical Case Report

Primary diffuse large B-cell lymphoma of the mandible

Juliana Mota Siqueira; Patrícia Maria Fernandes; Andrea Cruz Ferraz de Oliveira; José Vassallo; Fábio de Abreu Alves; Graziella Chagas Jaguar

Downloads: 1
Views: 59

Abstract

Primary intraosseous non-Hodgkin lymphoma in the mandible is uncommon, representing about 0.6% of all extranodal lymphomas. We present the case of a 51-year-old male with a 4-month complaint of mandibular swelling and paresthesia, which had been previously submitted to an unsuccessful periodontal treatment. The intra-oral evaluation showed an extensive swelling with teeth mobility in the right mandible body. The panoramic radiography and computed tomography images showed an extensive osteolytic lesion. An incisional biopsy was performed and the histopathological and immunohistochemical analysis established the diagnosis of diffuse large B-cell lymphoma. The treatment included six cycles of chemotherapy with complete remission. The patient is under the seventh month of follow-up with no evidence of relapse. Although uncommon in the oral cavity, lymphoma should be considered in the differential diagnosis.

Keywords

Head and Neck Neoplasms, Lymphoma, Large B-Cell, Diffuse, Oral Medicine

References

Zapater E, Bagán JV, Carbonell F, Basterra J. Malignant lymphoma of the head and neck. Oral Dis. 2010;16(2):119-28. 10.1111/j.1601-0825.2009.01586.x.20374502

Thakral B, Zhou J, Medeiros LJ. Extranodal hematopoietic neoplasms and mimics in the head and neck: an update. Hum Pathol. 2015;46(8):1079-100. 10.1016/j.humpath.2015.05.007.26118762

Vega F, Lin P, Medeiros LJ. Extranodal lymphomas of the head and neck. Ann Diagn Pathol. 2005;9(6):340-50. 10.1016/j.anndiagpath.2005.09.020.16308165

Pereira DL, Fernandes DT, Santos-Silva AR, Vargas PA, Almeida OP, Lopes MA. Intraosseous non-Hodgkin lymphoma mimicking a periapical lesion. J Endod. 2015;41(10):1738-42. 10.1016/j.joen.2015.06.001.26234541

Pazoki A, Jansisyanont P, Ord RA. Primary non-Hodgkin’s lymphoma of the jaws: report of 4 cases and review of the literature. J Oral Maxillofac Surg. 2003;61(1):112-7. 10.1053/joms.2003.50018.12524617

Okahata R, Shimamoto H, Marutani K, et al. Diffuse large B-cell lymphoma of the mandible with periosteal reaction: A case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117(2):e228-32. 10.1016/j.oooo.2013.12.002.24439924

Jessri M, AbdulMajeed AA, Matias MA, Farah CS. A case of primary diffuse large B-cell non-Hodgkin’s lymphoma misdiagnosed as chronic periapical periodontitis. Aust Dent J. 2013;58(2):250-5. 10.1111/adj.12056.23713648

Donaduzzi LC, Reinheimer A, Silva MAR, et al. Primary diffuse large B cell lymphoma mimicking hyperplastic reactive lesion (lymphoma of the oral cavity). Case Rep Pathol. 2018;2018:1-9. 10.1155/2018/2981689.29552368

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. 10.3322/caac.21492.30207593

Jain P, Fayad LE, Rosenwald A, Young KH, O’Brien S. Recent advances in de novo CD5+ diffuse large B cell lymphoma. Am J Hematol. 2013;88(9):798-802. 10.1002/ajh.23467.23695956

Harada S, Suzuki R, Uehira K, et al. Molecular and immunological dissection of diffuse large B cell lymphoma: CD5+, and CD5-with CD10+groups may constitute clinically relevant subtypes. Leukemia. 1999;13(9):1441-7. 10.1038/sj.leu.2401487.10482997

Li S, Young KH, Medeiros LJ. Diffuse large B-cell lymphoma. Pathology. 2018;50(1):74-87. 10.1016/j.pathol.2017.09.006.29167021

Lin P, Dickason TJ, Fayad LE, et al. Prognostic value of MYC rearrangement in cases of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. Cancer. 2012;118(6):1566-73. 10.1002/cncr.26433.21882178

Thakral B, Medeiros LJ, Desai P, et al. Prognostic impact of CD5 expression in diffuse large B-cell lymphoma in patients treated with rituximab-EPOCH. Eur J Haematol. 2017;98(4):415-21. 10.1111/ejh.12847.28039906

Miyazaki K, Yamaguchi M, Suzuki R, et al. CD5-positive diffuse large B-cell lymphoma: A retrospective study in 337 patients treated by chemotherapy with or without rituximab. Ann Oncol. 2011;22(7):1601-7. 10.1093/annonc/mdq627.21199885

 

 

 


Publication date:
08/22/2019

5d5ef6c10e8825416cd7cd18 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections