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Death from pan-resistant superbug

Larry Nichols

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Acinetobacter baumannii has emerged as a pan-resistant superbug causing fatal infections in vulnerable patients. This report is the case of an immunosuppressed transplant patient with a fatal pneumonia due to pan-resistant Acinetobacter baumannii. Alternative therapy for resistant Acinetobacter infection is currently the subject of intense interest and research. This report illustrates the features of this type of emerging infectious disease and reviews some of the novel approaches to treatment.


Acinetobacter, Pneumonia, Drug resistance, Bacterial, Autopsy


Serifoglu I, Er Dedekarginoglu B, Savas Bozbas S, Akcay S, Haberal M. Clinical characteristics of Acinetobacter baumannii infection in solid-organ transplant recipients. Exp Clin Transplant. 2018;16(Suppl 1):171-5. [PMID:29528021]

Zhou S, Fan L, Wang Z, et al. Increasing rates of Acinetobacter baumannii infection and resistance in an oncology department. J Cancer Res Ther. 2018;14(1):68-71. []. [PMID:29516962]

Maciel WG, Silva KE, Croda J, et al. Clonal spread of carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit. J Hosp Infect. 2018;98(3):300-4. []. [PMID:29107079]

Asif M, Alvi IA, Rehman SU. Insight into Acinetobacter baumannii: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities. Infect Drug Resist. 2018;11:1249-60. []. [PMID:30174448]

Vazquez Guillamet C, Kollef MH. Acinetobacter pneumonia: improving outcomes with early identification and appropriate therapy. Clin Infect Dis. 2018;67(9):1455-62. []. [PMID:29741597]

Balkhair A, Al-Muharrmi Z, Al’Adawi B, et al. Prevalence and 30-day all-cause mortality of carbapenem and colistin resistant bacteraemias caused by Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae: a description of a decade long trend. Int J Infect Dis. 2019;14(19):30210-3. [].

Jones CA, Davis JS, Looke DF. Death from an untreatable infection may signal the start of the post-antibiotic era. Med J Aust. 2017;206(7):292-3. []. [PMID:28403759]

Bagińska N, Pichlak A, Górski A, Jończyk-Matysiak E. Specific and selective bacteriophages in the fight against multidrug-resistant Acinetobacter baumannii. Virol Sin. 2019:1-11. []. [PMID:31093881]

Schooley RT, Biswas B, Gill JJ, et al. Development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant acinetobacter baumannii infection. Antimicrob Agents Chemother. 2017;61(10):e00954-17. []. [PMID:28807909]

Saipriya K, Swathi CH, Ratnakar KS, Sritharan V. Quorum sensing system in Acinetobacter baumannii: a potential target for new drug development. J Appl Microbiol. 2019;00:1-13. []. [PMID:31102552]

El Hafi B, Rasheed SS, Abou Fayad AG, Araj GF, Matar GM. Evaluating the efficacies of Carbapenem/β-Lactamase inhibitors against Carbapenem-Resistant Gram-Negative Bacteria in vitro and in vivo. Front Microbiol. 2019;10:933. []. [PMID:31114565]

Dettweiler M, Lyles JT, Nelson K, et al. American Civil War plant medicines inhibit growth, biofilm formation, and quorum sensing by multidrug-resistant bacteria. Sci Rep. 2019;9(1):7692. []. [PMID:31118466]

Pouch SM, Patel G. Community of Practice – Multidrug-resistant Gram-Negative Bacterial infections in solid organ transplant recipients - Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019;18:e13594. []. [PMID:31102483]

Qureshi ZA, Hittle LE, O’Hara JA, et al. Colistin-resistant Acinetobacter baumannii: beyond carbapenem resistance. Clin Infect Dis. 2015;60(9):1295-303. []. [PMID:25632010]

Thorne A, Luo T, Durairajan NK, Kaye KS, Foxman B. Risk factors for endemic Acinetobacter Baumannii colonization: a case-case study. Am J Infect Control. 2019;19:30462-6. []. [PMID:31253551]




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