Adilson José Manuel de Oliveira; Vinicius Monteiro de Paula Guirado; Vitor Nagai Yamaki; Fernando Pereira Frasseto
We present a case of a young woman with an intramedullary lesion and symptoms of spinal cord compression (lower limbs weakness and urinary retention). The MRI images rendered the preoperative differential diagnoses of neurofibroma and schwannoma; however, teratoma was suspected with the intraoperative findings, which was confirmed by the histological report.
Teratoma of the central nervous system is a rare entity that originates from the embryonic tissues of the three primary embryonic leaflets classified as (i) mature, (ii) immature and (iii) malignant. The intramedullary teratoma comprises 0.2% of all central nervous system tumors. The clinical picture varies according to the site of the lesion, and the most frequent location is the medullary cone. The outcome is usually favorable when a complete resection is feasible. Although complete resection was not possible in our case, the patient had symptomatic improvement.
We present the case of a 35-year-old female, who was referred to our emergency department with a 3-month history of intense low back pain radiating to the lower limbs without any specific dermatome distribution, followed by a progressive loss of the lower limbs’ muscular strength, and urinary retention over the last month.
On the neurological examination, the patient presented a grade-III muscular strength for the hip flexion and extension on de right side, and grade-IV on the left side; foot drop on the right side, bilateral L1 to L5 hypoesthesia, bilateral exaggerated patellar reflex, and bilateral Babinski sign.
The laboratory workup was normal, the lumbar spine computed tomography (CT) showed intra-spinal canal injury with scarce zones of calcification in the topography of the second to the fourth lumbar vertebra (
Intradural location of teratomas is rare and intramedullary teratomas are especially occasional. In 1931, Hosoi
Concerning the tumor pathogenesis, it is mostly accepted that the spinal teratoma arises from primordial germ cells misplaced from the primitive yolk sac into the dorsal midline during their normal migration from the yolk sac to gonadal ridges.
Differently from our case, the teratomas are three times more frequent in men than in women often associated with spinal disorders including spina bifida, split cord malformation, meningomyelocele and lipomeningomyelocele.
Our case is an illustrative case with the learning focused on two main aspects:
We did not indicate the adjuvant radiotherapy due to the lack of beneficial evidence. Even in the presence of recurrences, the tumor growth is very slow, and no evidence showed that the radiotherapy changed the outcome.
Intradural spinal teratomas are very rare and even more in adults. The heterogeneous signal shown by MRI images can indicate the solid or cystic composition of the tumor, which is extremely helpful for early diagnosis. The complete resection is the therapy of choice with attention focused on the neurological functions’ preservation.
This is an illustrative report of an unexpected diagnosis. This case emphasizes the importance to consider the diagnosis of teratoma among the differential diagnosis of cases with the clinical picture of compression of the medullary cone.
The patient signed the informed consent authorizing the data publication, and the manuscript is by the authorization of the institutional ethics committee.