Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2019.099
Autopsy and Case Reports
Article / Clinical Case Report

Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group

Pakesh Baishya; Jonali Das; Darilin Shangpliang; Biswajit Dey; Evarisalin Marbaniang; Donboklang Lynser; Yookarin Khonglah; Vandana Raphael

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Abstract

Granular cell tumor (GCT) is a rare soft tissue neoplasm of Schwann cell origin. Most cases occur in adults; however, the precise incidence is unknown in children. GCT is usually a slow-growing, painless tumor involving the skin and soft tissues that is mostly located in the head and neck region, especially the tongue. The breast is one of the least common sites involved by GCT. This paper presents a 3-year-old girl who presented with a soft to firm, ill-defined swelling on the right breast with painful ulceration of the overlying skin. Fine needle aspiration rendered an initial diagnosis of fibrocystic change accompanied by apocrine metaplasia. Histologic evaluation of the excised breast mass revealed a benign granular cell tumor. Although rare, GCT of the breast should be included in the differential diagnosis for breast masses in pediatric patients. Proper diagnosis and timely management of this tumor are essential because of its malignant potential (<2% of cases) and high rate of local recurrence if not properly excised.

Keywords

Breast, Schwann Cells, S100 Proteins

References

Bean SM, Eloubeidi MA, Eltoum IA, Cerfolio RJ, Jhala DN, Preoperative diagnosis of a mediastinal granular cell tumour by EUS-FNA: a case report and review of the literature. Cytojournal. 2005;2(8):1-8.

Diniz G, Vuruskaner H, Celebiler H, Ortac R, Aktas S, Ozener V. On üç yaşında bir kız çocukta, uyluk yumuşak dokusunda lokalize granüler hücreli tümör olgusu. Türkiye Ekopatoloji Dergisi. 2005;11(1):33-6.

Nasier H, Danfort RD Jr, Sunbuli M, Dimitrijevic O. Malignant granular cell tumour: case report with a novel karyotype and review of the literature. Ann Diagn Pathol. 2010;14(4):273-8. [https://doi.org/10.1016/j.anndiagpath.2009.08.004]. [PMID:20637434]

Ravich A, Stout AP, Ravich RA. Malignant granular cell myoblastoma involving the urinary bladder. Ann Surg. 1945;121(3):361-72. [https://doi.org/10.1097/00000658-194503000-00010]. [PMID:17858577]

Rexeena B, Paul A, Nitish RA, Kurian C, Anila RK. Granular cell tumour of breast: a case report and review of literature. Indian J Surg Oncol. 2015;6(4):446-8.

Becelli R, Perugini M, Gasparini G, Cassoni A, Fabiani F. Abrikissoff’s tumour. J Craniofac Surg. 2001;12(1):78-81. [https://doi.org/10.1097/00001665-200101000-00013]. [PMID:11314193]

Apisarnthanarax P. Granular cell tumor. An analysis of 16 cases and review of the literature. J Am Acad Dermatol. 1981;5(2):171-82. [https://doi.org/10.1016/S0190-9622(81)70085-9]. [PMID:6267110]

Adeniran A, Al-Ahmadie H, Mahoney MC, Robinson-Smith TM. Granular cell tumor of the breast: a series of 17 cases and review of the literature. Breast J. 2004;10(6):528-31. [https://doi.org/10.1111/j.1075-122X.2004.21525.x]. [PMID:15569210]

Yang WT, Edeiken-Monroe B, Sneige N, Fornage BD. Sonographic and mammographic appearances of granular cell tumors of the breast with pathological correlation. J Clin Ultrasound. 2006;34(4):153-60. [https://doi.org/10.1002/jcu.20227]. [PMID:16615051]

De Simone N, Aggon A, Christy C. Granular cell tumor of the breast: clinical and pathologic characteristics of a rare case in a 14-year-old girl. J Clin Oncol. 2011;29(22):e656-7. [https://doi.org/10.1200/JCO.2011.35.9448]. [PMID:21646617]

Marshall AP, Spottswood SE, Grau AM, Jackson JP. Juvenile fibroadenoma and granular cell tumor of the breast in an adolescent. J Pediatr Surg. 2012;47(10):1930-3. [https://doi.org/10.1016/j.jpedsurg.2012.07.050]. [PMID:23084210]

Heinzerling NP, Koehler SM, Szabo S, Wagner AJ. Pediatric granular cell tumor of the breast: a case report and review of the literature. Case Rep Surg. 2015;2015:568940. [https://doi.org/10.1155/2015/568940]. [PMID:26491597]

Omar L, Pfeifer CM, Kulkarni S, Sharma P, Sengupta A, Kwon JK. Granular cell tumor in a premenstrual female breast. Clin Imaging. 2018;52:334-6. [https://doi.org/10.1016/j.clinimag.2018.09.003]. [PMID:30241035]

Chung S, Noh WC. Fine needle aspiration cytology of granular cell tumor in breast- a case report. Korean J Cytopathol. 2007;8(2):157-60.

Stefansson K, Wollmann RL. S-100 protein in granular cell tumours (granular cell myoblastomas). Cancer. 1982;49(9):1834-8. [https://doi.org/10.1002/1097-0142(19820501)49:9<1834::AID-CNCR2820490916>3.0.CO;2-G]. [PMID:6280846]

Bellezza G, Colella R, Sidoni A, et al. Immunohistochemical expression og Galectin-3 and HMBE-1 in granular cell tumours: a new finding. Histol Histopathol. 2008;23(9):1127-30. [PMID:18581283]

Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumour of soft tissue; diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. 1998;22(7):779-94. [https://doi.org/10.1097/00000478-199807000-00001]. [PMID:9669341]

Le BH, Boyer PJ, Lewis JE, Kapadia SB. Granular cell tumour. Arch Pathol Lab Med. 2004;128(7):771-5. [PMID:15214825]

Abraham T, Jackson B, Davis I, Yu J, Peterson C. Mohs surgical treatment of a granular cell tumour on the toe of a child. Pediatr Dermatol. 2007;24(3):235-7. [https://doi.org/10.1111/j.1525-1470.2007.00392.x]. [PMID:17542870]

Lack EE, Worsham GF, Callihan MD, et al. Granular cell tumour: a clinicopathologic study of 110 patients. J Surg Oncol. 1980;13(4):301-16. [https://doi.org/10.1002/jso.2930130405]. [PMID:6246310]

 

 

 


Publication date:
07/12/2019

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