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Interesting post-mortem findings in a H1N1 influenza-positive pneumonia patient

Kolady Vijayakumar Vinu Balraam; Avnit Sidhu; Vadlamannati Srinivas

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Reports of histopathological findings in a patient infected with H1N1 influenza virus are limited in the literature, although many deaths have occurred because of this viral infection. In an otherwise healthy individual with no underlying co-morbid conditions, this virus passes off as a very mild disease. However, it can be fatal in the presence of underlying risk factors. Here, we present the autopsy findings of a patient who died of H1N1 infection, but who was apparently healthy with no predisposing ailments. The autopsy revealed chronic kidney disease and caseating granulomatous lymphadenitis in addition to the known classical diffuse alveolar damage picture seen in this condition. These underlying co-morbidities may provide greater insight and a better understanding of this infection.


Autopsy, Renal Insufficiency, Granuloma, Influenza A Virus, H1N1 Subtype


Prasad HB, Puranik SC, Kadam DB, et al. Retrospective analysis of necropsy findings in patients of H1N1 and their correlation to clinical features. J Assoc Physicians India. 2011;59:498-500. [PMID:21887906]

Taubenberger JK, Morens DM. The pathology of influenza virus infections. Annu Rev Pathol. 2008;3(1):499-522. []. [PMID:18039138]

Neumann G, Noda T, Kawaoka Y. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature. 2009;459(7249):931-9. []. [PMID:19525932]

Shelke VN, Kolhapure RM, Kadam D, et al. Pathologic study of pandemic influenza A (H1N1) 2009 cases from India. Pathol Int. 2012;62(1):36-42. []. [PMID:22192802]

Bal A, Suri V, Mishra B, et al. Pathology and virology findings in cases of fatal influenza A H1N1 virus infection in 2009-2010. Histopathology. 2012;60(2):326-35. []. [PMID:22211291]

Soto-Abraham MV, Soriano-Rosas J, Díaz-Quiñónez A, et al. Pathological changes associated with the 2009 H1N1 virus. N Engl J Med. 2009;361(20):2001-3. []. [PMID:19907053]

Mauad T, Hajjar LA, Callegari GD, et al. Lung pathology in fatal novel human influenza A (H1N1) infection. Am J Respir Crit Care Med. 2010;181(1):72-9. []. [PMID:19875682]

Gill JR, Sheng Z-M, Ely SF, et al. Pulmonary pathologic findings of fatal 2009 pandemic influenza A/H1N1 viral infections. Arch Pathol Lab Med. 2010;134(2):235-43. [PMID:20121613]

Harms PW, Schmidt LA, Smith LB, et al. Autopsy findings in eight patients with fatal H1N1 influenza. Am J Clin Pathol. 2010;134(1):27-35. []. [PMID:20551263]




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