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Primary colonic liposarcomatosis: report of a case with review of literature

Mahesh Sultania; Dillip Muduly; Shilpy Jha; Madhabananda Kar; Suvradeep Mitra

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The colon is a rare site of occurrence of liposarcoma, as either the primary site or by secondary involvement from a retroperitoneal liposarcoma. Liposarcomatosis denotes simultaneous occurrence of multiple liposarcomas. There are only 17 cases of primary colonic liposarcoma reported in the English literature—one of which was primary colonic liposarcomatosis. We depict the second case of primary colonic liposarcomatosis in a 57-year-old female who presented with abdominal swelling and pain. On exploratory laparotomy, two large masses were seen arising from the wall of the right colon along with multiple smaller masses attached to the colon. Right hemicolectomy with en bloc excision of the masses was performed along with hysterectomy and pelvic floor repair. Macroscopically, multiple exophytic masses and one endophytic mass were identified. The exophytic masses were of variable size and were found to hang from the colon by a thin pedicle simulating variable-sized appendices epiploicae. Histopathologically, the lesions showed the morphology of well-differentiated liposarcoma. This appears to be a case of primary colonic liposarcomatosis. There is only one other similar case reported in the English literature, to the best of our knowledge.


Liposarcoma, Colonic Neoplasms, Proto-Oncogene Proteins c-mdm2


Sawayama H, Yoshida N, Miyamoto Y, et al. Primary colonic well-differentiated/dedifferentiated liposarcoma of the ascending colon: a case report. Surg Case Rep. 2017;3(1):96. 10.1186/s40792-017-0373-4.28856628

Choi YY, Kim YJ, Jin SY. Primary liposarcoma of the ascending colon: a rare case of mixed type presenting as hemoperitoneum combined with other type of retroperitoneal liposarcoma. BMC Cancer. 2010;10(1):239. 10.1186/1471-2407-10-239.20507577

Chou CK, Chen ST. Computed tomography identification of an exophytic colonic liposarcoma. Radiol Case Rep. 2016;11(3):161-4. 10.1016/j.radcr.2016.06.005.27594941

D’Annibale M, Cosimelli M, Covello R, Stasi E. Liposarcoma of the colon presenting as an endoluminal mass. World J Surg Oncol. 2009;7(1):78. 10.1186/1477-7819-7-78.19852822

Dalal KM, Kattan MW, Antonescu CR, Brennan MF, Singer S. Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity, or trunk. Ann Surg. 2006;244(3):381-91.16926564

Türkoğlu MA, Elpek GO, Dogru V, Calış H, Uçar A, Arıcı C. An unusual case of primary colonic dedifferentiated liposarcoma. Int J Surg Case Rep. 2014;5(1):8-11. 10.1016/j.ijscr.2013.10.013.24394854

Fernandes SR, Rita Goncalves A, Lopes J, et al. Primary liposarcoma of the sigmoid presenting as colonic intussusception - A case report. Rev Esp Enferm Dig. 2016;108(9):591-4.26785977

Kito Y, Fujii T, Nishiyama T, et al. Peduncular liposarcoma of the colon: a case report and literature review. J Gastrointest Cancer. 2014;45(Suppl. 1):248-51. 10.1007/s12029-014-9647-2.25216753

Yaren A, Degirmencioglu S, Calli Demirkan N, Gokcen Demiray A, Taskoylu B, Gokoz Dogu G. Primary mesenchymal tumors of the colon: a report of three cases. Turk J Gastroenterol. 2014;25(3):314-8. 10.5152/tjg.2014.4010.25141322

Rudnicki C, Romanowski M, Medrek-Socha M, Stec-Michalska K. The diagnosis of sigmoid liposarcoma in a young male with metabolic syndrome. J Clin Diagn Res. 2015;9(12):OD01-03.26816934

Wood DL, Morgenstern L. Liposarcoma of the ileocecal valve: a case report. Mt Sinai J Med. 1989;56(1):62-4.2784186

Parks RW, Mullan FJ, Kamel HM, Walsh MY, McKelvey ST. Liposarcoma of the colon. Ulster Med J. 1994;63(1):111-3.8658985

Magro G, Gurrera A, Di Cataldo A, Licata A, Vasquez E. Well-differentiated lipoma-like liposarcoma of the caecum. Histopathology. 2000;36(4):378-80. 10.1046/j.1365-2559.2000.0855d.x.10841651

Chen KT. Liposarcoma of the colon: a case report. Int J Surg Pathol. 2004;12(3):281-5. 10.1177/106689690401200312.15306943

Gutsu E, Ghidirim G, Gagauz I, Mishin I, Iakovleva I. Liposarcoma of the colon: a case report and review of literature. J Gastrointest Surg. 2006;10(5):652-6. 10.1016/j.gassur.2005.09.014.16773759

Shahidzadeh R, Ponce CR, Lee JR, Chamberlain SM. Liposarcoma in a colonic polyp: case report and review of the literature. Dig Dis Sci. 2007;52(12):3377-80. 10.1007/s10620-007-9806-4.17393311

Chaudhary A, Arora R, Sharma A, Aggarwal S, Safaya R, Sharma S. Primary colonic liposarcoma causing colo-colic intusussception: a case report and review of literature. J Gastrointest Cancer. 2007;38(2-4):160-3. 10.1007/s12029-008-9031-1.18972225

Jarboui S, Moussi A, Jarraya H, et al. Primary dedifferentiated liposarcoma of the colon: a case report. Gastroenterol Clin Biol. 2009;33(10-11):1016-8. 10.1016/j.gcb.2008.11.014.19272723

Lewis JJ, Leung D, Woodruff JM, Brennan MF. Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Ann Surg. 1998;228(3):355-65. 10.1097/00000658-199809000-00008.9742918

Thomas JM. Retroperitoneal sarcoma. Br J Surg. 2007;94(9):1057-8. 10.1002/bjs.5967.17701955

Hughes TM, Spillane AJ. Imaging of soft tissue tumours. Br J Surg. 2000;87(3):259-60. 10.1046/j.1365-2168.2000.01412.x.10718790

Hoffman A, Lazar AJ, Pollock RE, Lev D. New frontiers in the treatment of liposarcoma, a therapeutically resistant malignant cohort. Drug Resist Updat. 2011;14(1):52-66. 10.1016/j.drup.2010.11.001.21169051

Jones RL, Fisher C, Al-Muderis O, Judson IR. Differential sensitivity of liposarcoma subtypes to chemotherapy. Eur J Cancer. 2005;41(18):2853-60. 10.1016/j.ejca.2005.07.023.16289617




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