Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2018.056
Autopsy and Case Reports
Article / Clinical Case Report

Primary colonic liposarcomatosis: report of a case with review of literature

Mahesh Sultania; Dillip Muduly; Shilpy Jha; Madhabananda Kar; Suvradeep Mitra

Downloads: 0
Views: 388

Abstract

The colon is a rare site of occurrence of liposarcoma, as either the primary site or by secondary involvement from a retroperitoneal liposarcoma. Liposarcomatosis denotes simultaneous occurrence of multiple liposarcomas. There are only 17 cases of primary colonic liposarcoma reported in the English literature—one of which was primary colonic liposarcomatosis. We depict the second case of primary colonic liposarcomatosis in a 57-year-old female who presented with abdominal swelling and pain. On exploratory laparotomy, two large masses were seen arising from the wall of the right colon along with multiple smaller masses attached to the colon. Right hemicolectomy with en bloc excision of the masses was performed along with hysterectomy and pelvic floor repair. Macroscopically, multiple exophytic masses and one endophytic mass were identified. The exophytic masses were of variable size and were found to hang from the colon by a thin pedicle simulating variable-sized appendices epiploicae. Histopathologically, the lesions showed the morphology of well-differentiated liposarcoma. This appears to be a case of primary colonic liposarcomatosis. There is only one other similar case reported in the English literature, to the best of our knowledge.

Keywords

Liposarcoma, Colonic Neoplasms, Proto-Oncogene Proteins c-mdm2

References

Sawayama H, Yoshida N, Miyamoto Y, et al. Primary colonic well-differentiated/dedifferentiated liposarcoma of the ascending colon: a case report. Surg Case Rep. 2017;3(1):96. [https://doi.org/10.1186/s40792-017-0373-4]. [PMID:28856628]

Choi YY, Kim YJ, Jin SY. Primary liposarcoma of the ascending colon: a rare case of mixed type presenting as hemoperitoneum combined with other type of retroperitoneal liposarcoma. BMC Cancer. 2010;10(1):239. [https://doi.org/10.1186/1471-2407-10-239]. [PMID:20507577]

Chou CK, Chen ST. Computed tomography identification of an exophytic colonic liposarcoma. Radiol Case Rep. 2016;11(3):161-4. [https://doi.org/10.1016/j.radcr.2016.06.005]. [PMID:27594941]

D’Annibale M, Cosimelli M, Covello R, Stasi E. Liposarcoma of the colon presenting as an endoluminal mass. World J Surg Oncol. 2009;7(1):78. [https://doi.org/10.1186/1477-7819-7-78]. [PMID:19852822]

Dalal KM, Kattan MW, Antonescu CR, Brennan MF, Singer S. Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity, or trunk. Ann Surg. 2006;244(3):381-91. [PMID:16926564]

Türkoğlu MA, Elpek GO, Dogru V, Calış H, Uçar A, Arıcı C. An unusual case of primary colonic dedifferentiated liposarcoma. Int J Surg Case Rep. 2014;5(1):8-11. [https://doi.org/10.1016/j.ijscr.2013.10.013]. [PMID:24394854]

Fernandes SR, Rita Goncalves A, Lopes J, et al. Primary liposarcoma of the sigmoid presenting as colonic intussusception - A case report. Rev Esp Enferm Dig. 2016;108(9):591-4. [PMID:26785977]

Kito Y, Fujii T, Nishiyama T, et al. Peduncular liposarcoma of the colon: a case report and literature review. J Gastrointest Cancer. 2014;45(Suppl. 1):248-51. [https://doi.org/10.1007/s12029-014-9647-2]. [PMID:25216753]

Yaren A, Degirmencioglu S, Calli Demirkan N, Gokcen Demiray A, Taskoylu B, Gokoz Dogu G. Primary mesenchymal tumors of the colon: a report of three cases. Turk J Gastroenterol. 2014;25(3):314-8. [https://doi.org/10.5152/tjg.2014.4010]. [PMID:25141322]

Rudnicki C, Romanowski M, Medrek-Socha M, Stec-Michalska K. The diagnosis of sigmoid liposarcoma in a young male with metabolic syndrome. J Clin Diagn Res. 2015;9(12):OD01-03. [PMID:26816934]

Wood DL, Morgenstern L. Liposarcoma of the ileocecal valve: a case report. Mt Sinai J Med. 1989;56(1):62-4. [PMID:2784186]

Parks RW, Mullan FJ, Kamel HM, Walsh MY, McKelvey ST. Liposarcoma of the colon. Ulster Med J. 1994;63(1):111-3. [PMID:8658985]

Magro G, Gurrera A, Di Cataldo A, Licata A, Vasquez E. Well-differentiated lipoma-like liposarcoma of the caecum. Histopathology. 2000;36(4):378-80. [https://doi.org/10.1046/j.1365-2559.2000.0855d.x]. [PMID:10841651]

Chen KT. Liposarcoma of the colon: a case report. Int J Surg Pathol. 2004;12(3):281-5. [https://doi.org/10.1177/106689690401200312]. [PMID:15306943]

Gutsu E, Ghidirim G, Gagauz I, Mishin I, Iakovleva I. Liposarcoma of the colon: a case report and review of literature. J Gastrointest Surg. 2006;10(5):652-6. [https://doi.org/10.1016/j.gassur.2005.09.014]. [PMID:16773759]

Shahidzadeh R, Ponce CR, Lee JR, Chamberlain SM. Liposarcoma in a colonic polyp: case report and review of the literature. Dig Dis Sci. 2007;52(12):3377-80. [https://doi.org/10.1007/s10620-007-9806-4]. [PMID:17393311]

Chaudhary A, Arora R, Sharma A, Aggarwal S, Safaya R, Sharma S. Primary colonic liposarcoma causing colo-colic intusussception: a case report and review of literature. J Gastrointest Cancer. 2007;38(2-4):160-3. [https://doi.org/10.1007/s12029-008-9031-1]. [PMID:18972225]

Jarboui S, Moussi A, Jarraya H, et al. Primary dedifferentiated liposarcoma of the colon: a case report. Gastroenterol Clin Biol. 2009;33(10-11):1016-8. [https://doi.org/10.1016/j.gcb.2008.11.014]. [PMID:19272723]

Lewis JJ, Leung D, Woodruff JM, Brennan MF. Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Ann Surg. 1998;228(3):355-65. [https://doi.org/10.1097/00000658-199809000-00008]. [PMID:9742918]

Thomas JM. Retroperitoneal sarcoma. Br J Surg. 2007;94(9):1057-8. [https://doi.org/10.1002/bjs.5967]. [PMID:17701955]

Hughes TM, Spillane AJ. Imaging of soft tissue tumours. Br J Surg. 2000;87(3):259-60. [https://doi.org/10.1046/j.1365-2168.2000.01412.x]. [PMID:10718790]

Hoffman A, Lazar AJ, Pollock RE, Lev D. New frontiers in the treatment of liposarcoma, a therapeutically resistant malignant cohort. Drug Resist Updat. 2011;14(1):52-66. [https://doi.org/10.1016/j.drup.2010.11.001]. [PMID:21169051]

Jones RL, Fisher C, Al-Muderis O, Judson IR. Differential sensitivity of liposarcoma subtypes to chemotherapy. Eur J Cancer. 2005;41(18):2853-60. [https://doi.org/10.1016/j.ejca.2005.07.023]. [PMID:16289617]

 

 

 


Publication date:
01/14/2019

5c3cdbb00e8825970ccd6223 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections