Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2018.055
Autopsy and Case Reports
Article / Autopsy Case Report

Intravascular large B-cell lymphoma: The Great Imitator

Katherine Ann Devitt; Juli-Anne Gardner

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Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma with an estimated incidence of less than one per million. Unlike other hematopoietic malignancies, lymphadenopathy and hepatosplenomegaly are uncommon, and patients typically present with nonspecific symptoms. IVLBCL presents a diagnostic challenge and patients are usually diagnosed late in the disease course, if at all, and the prognosis is poor. The differential diagnosis is broad, and physicians often pursue multiple diagnostic possibilities during patient workup. We present a case of IVLBCL discovered at autopsy in an 80-year-old male who presented with history and symptoms pointing to the tick-borne illness ehrlichiosis.

Keywords

Lymphoma, non-Hodgkin, Lymphoma, B-cell, Ehrlichiosis, Blood Vessels, Autopsy

References

Rikihisa Y. Molecular pathogenesis of Ehrlichia chaffeensis infection. Annu Rev Microbiol. 2015;69(1):283-304. [https://doi.org/10.1146/annurev-micro-091014-104411]. [PMID:26488275]

Stone JH, Dierberg K, Aram G, Dumler JS. Human monocytic ehrlichiosis. JAMA. 2004;292(18):2263-70. [https://doi.org/10.1001/jama.292.18.2263]. [PMID:15536115]

Yachoui R. Multiorgan failure related to human monocytic ehrlichiosis. BMJ Case Rep. 2013;2013(may22 1):1-2. [https://doi.org/10.1136/bcr-2013-008716]. [PMID:23704428]

Zuckerman D, Seliem R, Hochberg E. Intravascular lymphoma: the oncologist’s “great imitator”. Oncologist. 2006;11(5):496-502. [https://doi.org/10.1634/theoncologist.11-5-496]. [PMID:16720850]

Kivity S, Shalmon B, Sidi Y. Guillain-Barre syndrome: an unusual presentation of intravascular lymphoma. Isr Med Assoc J. 2006;8(2):137-8. [PMID:16544742]

Luo B, Chen JM, Liu J, et al. A case of intravascular large B-cell lymphoma presenting as nodular goiter. Diagn Pathol. 2017;12(64):1-4. [https://doi.org/10.1186/s13000-017-0656-x]. [PMID:28841887]

Brett FM, Chen D, Loftus T, Langan Y, Looby S, Hutchinson S. Intravascular large B-cell lymphoma presenting clinically as rapidly progressive dementia. Ir J Med Sci. 2018;187(2):319-22. [https://doi.org/10.1007/s11845-017-1653-5]. [PMID:28726030]

Takeshige T, Harada N, Sekimoto Y, et al. Pulmonary intravascular large B-cell lymphoma (IVLBCL) disguised as an asthma exacerbation in a patient with asthma. Intern Med. 2017;56(14):1885-91. [https://doi.org/10.2169/internalmedicine.56.7613]. [PMID:28717087]

Fischer M, Iglseder S, Grams A, et al. Intravascular large B-cell lymphoma mimicking central nervous system vasculitis. Hum Pathol Case Rep. 2017;8:3-8.

Nakamura S, Ponzoni M, Campo E. Intravascular large B-cell lymphoma. In: Swerdlow SH, Campo E, Harris NL, et al. editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: International Agency for Research of Cancer; 2017. p. 317-8.

Banjongjit A, Chiratikarnwong K, Saelue P, Sangmala S, Auepemkiate S, Kayasut K. Random skin biopsy for diagnosis of intravascular large B-cell lymphoma in a patient with hypoxemia and normal lung imaging. JAAD Case Rep. 2018;4(2):149-51. [https://doi.org/10.1016/j.jdcr.2017.11.013]. [PMID:29387769]

García-Muñoz R, Rubio-Mediavilla S, Robles-de-Castro D, Muñoz A, Herrera-Pérez P, Rabasa P. Intravascular large B cell lymphoma. Leuk Res Rep. 2014;3(1):21-3. [https://doi.org/10.1016/j.lrr.2013.12.002]. [PMID:24596677]

 

 

 


Publication date:
11/30/2018

5c0178850e88255b59e94201 autopsy Articles
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