Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2018.051
Autopsy and Case Reports
Article / Autopsy Case Report

Late stillbirth due to listeriosis

Antonio Segado-Arenas; Lidia Atienza-Cuevas; José Roman Broullón-Molanes; Moisés Rodríguez-González; Simón Pedro Lubián-López

Downloads: 2
Views: 465

Abstract

Listeriosis is a sporadic infectious disease, which affects high-risk populations, such as the elderly, pregnant women, newborns, and immunocompromised patients. During pregnancy, listeriosis usually presents like a mild non-specific infection, but it may be responsible for fetal loss, preterm labor, early onset neonatal sepsis, and neonatal death. We report the case of a late stillbirth secondary to maternal chorioamnionitis. Listeria monocytogenes was isolated from the amniotic fluid and the fetal pleural fluid. The fetal autopsy revealed a disseminated inflammatory response with multi-organ involvement. This case illustrates the importance of the prevention and the diagnosis of listeriosis during gestation and may help us to understand the physiopathology of fetal loss due to listeriosis.

Keywords

Listeria Monocytogenes, Stillbirth, Infant, Newborn, Chorioamnionitis, Autopsy

References

Sapuan S, Kortsalioudaki C, Anthony M, et al. Neonatal listeriosis in the UK 2004 e 2014. J Infect. 2017;74(3):236-42. [https://doi.org/10.1016/j.jinf.2016.11.007]. [PMID:27867063]

Allerberger F, Wagner M. Listeriosis: a resurgent foodborne infection. Clin Microbiol Infect. 2010;16(1):16-23. [PMID:20002687]

Sisó C, Goncé A, Bosch J, Salvia MD, Hernández S, Figueras F. Listeriosis in pregnancy: a secular trend in a tertiary referral hospital in Barcelona. Eur J Clin Microbiol Infect Dis. 2012;31(9):2125-32. [https://doi.org/10.1007/s10096-012-1545-6]. [PMID:22327372]

The American College of Obstetricians and Gynecologists. Committee opinion nº 614: management of pregnant women with presumptive exposure to Listeria monocytogenes. Obstet Gynecol. 2014;124(6):1241-4. [https://doi.org/10.1097/01.AOG.0000457501.73326.6c]. [PMID:25411758]

Janakiraman V. Listeriosis in pregnancy: diagnosis, treatment, and prevention. Rev Obstet Gynecol. 2008;1(4):179-85. [PMID:19173022]

Wadhwa Desai R, Smith MA. Pregnancy-related listeriosis. Birth Defects Res. 2017;109(5):324-35. [https://doi.org/10.1002/bdr2.1012]. [PMID:28398675]

McClure EM, Goldenberg RL. Seminars in fetal & neonatal medicine infection and stillbirth. Semin Fetal Neonatal Med. 2009;14(4):182-9. [https://doi.org/10.1016/j.siny.2009.02.003]. [PMID:19285457]

Baud D, Greub G. Intracellular bacteria and adverse pregnancy outcomes. Clin Microbiol Infect. 2011;17(9):1312-22. [https://doi.org/10.1111/j.1469-0691.2011.03604.x]. [PMID:21884294]

Silva FT, Gonik B, McMillan M, et al. Stillbirth: case definition and guidelines for data collection, analysis, and presentation of maternal immunization safety data. Vaccine. 2016;34(49):6057-68. [https://doi.org/10.1016/j.vaccine.2016.03.044]. [PMID:27431422]

Mylonakis E, Paliou M, Hohmann EL, Calderwood SB, Wing EJ. Listeriosis during pregnancy: a case series and review of 222 cases. Medicine. 2002;81(4):260-9. [https://doi.org/10.1097/00005792-200207000-00002]. [PMID:12169881]

Monari F, Gabrielli L, Gargano G, et al. Fetal bacterial infections in antepartum stillbirth: a case series. Early Hum Dev. 2013;89(12):1049-54. [https://doi.org/10.1016/j.earlhumdev.2013.08.010]. [PMID:24041816]

Barikbin P, Sallmon H, Huseman D, et al. Clinical, laboratory, and placental findings in perinatal Listeriosis. Fetal Pediatr Pathol. 2016;35(5):307-14. [https://doi.org/10.1080/15513815.2016.1179822]. [PMID:27212240]

Lamont RF, Sobel J, Mazaki-Tovi S, et al. Listeriosis in human pregnancy: a systematic review. J Perinat Med. 2011;39(3):227-36. [https://doi.org/10.1515/jpm.2011.035]. [PMID:21517700]

Kaur S, Malik SVS, Vaidya VM, Barbuddhe SB. Listeria monocytogenes in spontaneous abortions in humans and its detection by multiplex PCR. J Appl Microbiol. 2007;103(5):1889-96. [https://doi.org/10.1111/j.1365-2672.2007.03414.x]. [PMID:17953598]

Le Monnier A, Abachin E, Beretti JL, Berche P, Kayal S. Diagnosis of Listeria monocytogenes meningoencephalitis by real-time PCR for the hly gene. J Clin Microbiol. 2011;49(11):3917-23. [https://doi.org/10.1128/JCM.01072-11]. [PMID:21918022]

 

 

 


Publication date:
10/22/2018

5bce20a50e8825830c1f4c0b autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections