Autopsy and Case Reports
Autopsy and Case Reports
Article / Clinical Case Report

Solitary extranodal Rosai-Dorfman disease of the mandible: an exceedingly rare presentation

Ameer Hamza; Zhifei Zhang; Basim Al-Khafaji

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Sinus histiocytosis with massive lymphadenopathy, generally known by the name of Rosai-Dorfman disease is a rare benign condition principally affecting cervical lymph nodes. Concurrent extra-nodal disease frequently occurs, however, solitary extra-nodal disease involving the mandible is exceedingly rare with less than five reported cases in the English literature. We describe a case of primary involvement of the mandible in a 27-year-old female, and discuss the differential diagnosis of this disease with other histiocytic lesions.


Histiocytosis, Sinus, Histiocytosis, NonLangerhan-cell, Mandible


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