Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2018.035
Autopsy and Case Reports
Article / Autopsy Case Report

Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation

Gabriel Lorente Mitsumoto; Fabiola Del Carlo Bernardi; Juliana Fracalossi Paes; Luisa Lina Villa; Barbara Mello; Geanete Pozzan

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Abstract

Papilloma associated with recurrent respiratory papillomatosis (RRP), caused by human papilloma virus (HPV) infection types 6 and 11, is the most common benign neoplasm of the larynx. The clinical features of RRP vary widely from mild to aggressive forms. RRP in children is known as juvenile-onset recurrent respiratory papillomatosis (JORRP). Its outcome may be poor or even fatal due to the high rate of recurrence and eventual spread to the entire respiratory tract. Pulmonary invasion is reported to occur in 3.3% of patients with RRP, and malignant transformation in 0.5% of patients. We report the case of a 39-year-old female patient with a diagnosis of JORRP from the age of 3 years, with extensive bilateral pulmonary involvement and malignant transformation. Analysis of the papilloma and carcinomatous tissues revealed the presence of HPV type 11, which is associated with rapid and aggressive progression. We discussed the case on the basis of a literature review on pulmonary invasion, malignant transformation, and HPV 11 aggressiveness.

Keywords

Carcinoma, Squamous Cell, Human Papillomavirus 11, Lung Neoplasms, Papillomavirus Infections, Recurrent Respiratory Papillomatosis

References

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Publication date:
07/13/2018

5b4901040e88254130d6b02b autopsy Articles
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