Autopsy and Case Reports
Autopsy and Case Reports
Article / Clinical Case Report

Solitary pancreatic renal cell carcinoma metastasis

Miguel Nogueira; Sílvia Costa Dias; Ana Catarina Silva; João Pinto; Jorge Machado

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Pancreatic metastases are rare; they account for only 2% of all pancreatic malignancies and usually occur when associated with a disseminated metastatic disease. Solitary pancreatic metastases are even less frequent, and there are few reports regarding surgical resection. We report the case of a 77-year-old female patient diagnosed with a single cephalo-pancreatic metastasis of renal cell carcinoma, 16 years after a total nephrectomy. The patient underwent successful pancreaticoduodenectomy, and the diagnosis was confirmed. A subsequent positron emission tomography (PET) scan showed disease relapse, and tyrosine kinase inhibitor treatment with sunitinib was initiated. After 1 year and 4 months, the PET-computed tomography scan showed a complete radiologic response.


Neoplasm Metastasis, Carcinoma, Kidney Neoplasm, Pancreas


Sperti C, Moletta L, Patanè G. Metastatic tumors to the pancreas: the role of surgery. World J Gastrointest Oncol. 2014;6(10):381-92. []. [PMID:25320654]

Klein KA, Stephens DH, Welch TJ. CT characteristics of metastatic disease of the pancreas. Radiographics. 1998;18(2):369-78. []. [PMID:9536484]

Scatarige JC, Horton KM, Sheth S, Fishman EK. Pancreatic parenchymal metastases: observations on helical CT. AJR Am J Roentgenol. 2001;176(3):695-9. []. [PMID:11222207]

Muranaka T, Teshima K, Honda H, Nanjo T, Hanada K, Oshiumi Y. Computed tomography and histologic appearance of pancreatic metastases from distant sources. Acta Radiol. 1989;30(6):615-9. []. [PMID:2631949]

Ferrozzi F, Bova D, Campodonico F, Chiara FD, Passari A, Bassi P. Pancreatic metastases: CT assessment. Eur Radiol. 1997;7(2):241-5. []. [PMID:9038124]

Yoshinaga S, Suzuki H, Oda I, Saito Y. Role of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for diagnosis of solid pancreatic masses. Dig Endosc. 2011;23(Suppl. 1):29-33. []. [PMID:21535197]

Pantuck AJ, Zisman A, Belldegrun AS. The changing natural history of renal cell carcinoma. J Urol. 2001;166(5):1611-23. []. [PMID:11586189]

Ritchie AW, Chisholm GD. The natural history of renal carcinoma. Semin Oncol. 1983;10(4):390-400. [PMID:6665566]

Tanis PJ, van der Gaag NA, Busch OR, van Gulik TM, Gouma DJ. Systematic review of pancreatic surgery for metastatic renal cell carcinoma. Br J Surg. 2009;96(6):579-92. []. [PMID:19434703]

Zerbi A, Ortolano E, Balzano G, Borri A, Beneduce AA, Di Carlo V. Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection? Ann Surg Oncol. 2008;15(4):1161-8. []. [PMID:18196343]

Yagi T, Hashimoto D, Taki K, et al. Surgery for metastatic tumors of the pancreas. Surg Case Rep. 2017;3(1):31. []. [PMID:28214950]

Raman SP, Hruban RH, Cameron JL, Wolfgang CL, Fishman EK. Pancreatic imaging mimics: Part 2, pancreatic neuroendocrine tumors and their mimics. AJR Am J Roentgenol. 2012;199(2):309-18. []. [PMID:22826391]

Itoi T, Tsuchiya T, Itokawa F, et al. Histological diagnosis by EUS-guided fine-needle aspiration biopsy in pancreatic solid masses without on-site cytopathologist: A single-center experience. Dig Endosc. 2011;23(Suppl. 1):34-8. []. [PMID:21535198]

Escudier B, Porta C, Schmidinger M, et al. Renal cell carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016;27(Suppl. 5):v58-68. []. [PMID:27664262]








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