Autopsy and Case Reports
Autopsy and Case Reports
Article / Clinical Case Report

Metastatic castration-resistant prostate cancer and the challenge of a patient with chronic kidney disease in hemodialysis

Joana Simões; Isabel Augusto; Sara Meireles; Lurdes Vendeira; Carlos Silva

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At a time when the population shows increasing longevity, entities such as cancer and chronic kidney disease (CKD) are more frequently connected. In the United States, approximately 6% of the patients on hemodialysis have cancer. The challenge to manage oncologic patients with CKD in a hemodialytic program represents a great shortage of available information on the choice of the best drug, timing, dosage adjustments, dialysis method, and treatment safety. We present the case of a patient with prostate cancer and terminal CKD in hemodialysis, and the treatment sequence after the development of resistance to hormonal blockade therapy, which included docetaxel, enzalutamide, and radium-223.


Prostate cancer, Dialysis, Docetaxel, Enzalutamide, Radium-223


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