Autopsy and Case Reports
Autopsy and Case Reports
Letter to the Editor

Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?

Cristiano Claudino Oliveira; Rafael Bispo Paschoalini; Maria Aparecida Custódio Domingues

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Histiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects. We evaluated in particular, if apoptosis may be unbalanced in this disease. All cases have morphological and immunohistochemical features consistent with the diagnosis of histiocytic sarcoma. The markers CD163, CD68, vimentin, lysozyme, and S-100 were positive in all cases. Similarly, the three samples were positive for Fas-ligand and Caspase-3. It is well-known that neoplasms may induce increased levels of Fas-ligand with the blockade of the apoptosis process. In the context of HS, the increased Fas-ligand expression represents a new area for research. Indeed, it is linked to proinflammatory stimulus and, maybe with the association of an infection.


Histiocytic sarcoma, Diagnosis, Immunohistochemistry


Swerdelow SH, Campo E, Harris ES, et al. WHO Classification of tumours of haematopoietic and Lymphoid Tissues. 5th ed. Lyon: International Agency for research on Cancer; 2017.

Emile JF, Abla O, Fraitag S, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016;127(22):2672-81. [PMID:26966089] [].

Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375-90. [PMID:26980727] [].

Hornick JL, Jaffe ES, Fletcher CDM. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol. 2004;28(9):1133-44. [PMID:15316312] [].

Caulfield AJ, Lathem WW. Disruption of Fas-Fas ligand signaling, apoptosis and innate immunity by bacterial pathogens. PLoS Pathog. 2014;10(8):e1004252. [PMID:25101900] [].

Bergantini APF, Castro FA, Souza AM, Fett-Conte AC. Chronic myeloid leukemia and the Fas-FasL system. Rev Bras Hematol Hemoter. 2005;27(2):120-5.

Peter ME, Hadji A, Murmann AE, et al. The role of Cd95 and CD95 ligand in cancer. Cell Death Differ. 2015;22(4):549-59. [PMID:25656654] [].

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