Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2017.030
Autopsy and Case Reports
Article / Clinical Case Report

Mantle cell lymphoma: involvement of nodal and extranodal sites in the head and neck, with multifocal oral lesions

Marcelo Marcucci; Gilberto Marcucci; Mirna Scalon Cordeiro; Jorge Esquiche León; Juliane Piragine Araujo; Jefferson Xavier de Oliveira; Karina Cecília Panelli Santos

Downloads: 1
Views: 800

Abstract

Mantle cell lymphoma (MCL) is a malignant B-cell neoplasm, which comprises monomorphic and small- to medium-sized mantle zone-derived lymphoid cells. It is characterized by chromosomal translocation t(11;14)(q13;q32) and CCND1 truncation, resulting in cell cycle deregulation. It is an aggressive type of non-Hodgkin lymphoma with a propensity to present with extranodal involvement. This study shows the case of an 80-year-old Caucasian male who complained of a 2-month progressive swelling on the right side of his face. The magnetic resonance imaging exam showed multifocal involvement of the head and neck, including oral manifestations, bilateral parotid glands, palate, tongue, and floor of the mouth. An incisional biopsy of the tumor mass was performed. The morphological and immunophenotypic findings were consistent with the diagnosis of MCL. The patient died 4 months later, without any chance of undergoing a therapeutic approach. Although MCL is a rare condition, it should be subjected to a differential diagnosis when affecting the maxillofacial area. Imaging exams and both immunohistochemical and morphological analyses are needed to reach the correct diagnosis. Here, we present an unusual MCL with multifocal involvement of the head and neck.

Keywords

Lymphoma, Mantle Cell, Oral Manifestations, Head and Neck Neoplasms, Magnetic Resonance Imaging, Salivary Glands

References

Skarbnik AP, Goy AH. Mantle cell lymphoma: state of the art. Clin Adv Hematol Oncol. 2015;13(1):44-55. [PMID:25679973]

Zhou Y, Wang H, Fang W, et al. Incidence trends of mantle cell lymphoma in the United States between 1992 and 2004. Cancer. 2008;113(4):791-8. [PMID:18615506] [https://doi.org/10.1002/cncr.23608].

Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M. Head and neck non-Hodgkin’s lymphoma: a 20-year demographic study of 381 cases. Int J Oral Maxillofac Surg. 2010;39(9):869-72. [PMID:20538427] [https://doi.org/10.1016/j.ijom.2010.03.029].

Triantafillidou K, Dimitrakopoulos J, Iordanidis F, Gkagkalis A. Extranodal non-Hodgkin lymphomas of the oral cavity and maxillofacial region: a clinical study of 58 cases and review of the literature. J Oral Maxillofac Surg. 2012;70(12):2776-85. [PMID:22494508] [https://doi.org/10.1016/j.joms.2012.01.018].

Barnes L, Eveson JW, Reichart P, Sidransky D, editors. Pathology and genetics of tumours of the head and neck. Lyon: IARC Press; 2005. v. 9.

Chen Y, Wang M, Romaguera J. Current regimens and novel agents for mantle cell lymphoma. Br J Haematol. 2014;167(1):3-18. [PMID:24974852] [https://doi.org/10.1111/bjh.13000].

Pilavaki M, Athanasiadou A, Iordanidis F, Karakozoglou T, Palladas P. Magnetic resonance imaging with pathological correlation in a case of mantle cell lymphoma of the parotid gland: a case report. J Med Case Reports. 2010;4(1):99. [PMID:20350332] [https://doi.org/10.1186/1752-1947-4-99].

Guggisberg K, Jordan RC. Mantle cell lymphoma of the oral cavity: case series and comprehensive review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(1):98-104. [PMID:19880332] [https://doi.org/10.1016/j.tripleo.2009.08.010].

Kyo C, Kawaoka Y, Kinoshita K, Ohno H. Mantle cell lymphoma presenting with a tumor of the hard palate. Intern Med. 2010;49(15):1663-6. [PMID:20686311] [https://doi.org/10.2169/internalmedicine.49.3436].

Guastafierro S, Falcone U, Celentano M, Cappabianca S, Giudice A, Colella G. Primary mantle-cell non-Hodgkin’s lymphoma of the tongue. Int J Hematol. 2008;88(2):206-8. [PMID:18629601] [https://doi.org/10.1007/s12185-008-0142-z].

Burke CJ, Thomas RH, Howlett D. Imaging the major salivary glands. Br J Oral Maxillofac Surg. 2011;49(4):261-9. [PMID:20381221] [https://doi.org/10.1016/j.bjoms.2010.03.002].

Lee YY, Wong KT, King AD, Ahuja AT. Imaging of salivary gland tumours. Eur J Radiol. 2008;66(3):419-36. [PMID:18337041] [https://doi.org/10.1016/j.ejrad.2008.01.027].

Jaffe ES. Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis. Mod Pathol. 2002;15(3):255-63. [PMID:11904341] [https://doi.org/10.1038/modpathol.3880521].

Economopoulos T, Papageorgiou S, Rontogianni D, et al. Multifocal extranodal non-Hodgkin lymphoma: a clinicopathologic study of 37 cases in Greece, a Hellenic Cooperative Oncology Group study. Oncologist. 2005;10(9):734-8. [PMID:16249354] [https://doi.org/10.1634/theoncologist.10-9-734].

Lenz G, Dreyling M, Hiddemann W. Mantle cell lymphoma: established therapeutic options and future directions. Ann Hematol. 2004;83(2):71-7. [PMID:14669040] [https://doi.org/10.1007/s00277-003-0774-2].

Gao J, Peterson L, Nelson B, Goolsby C, Chen YH. Immunophenotypic variations in mantle cell lymphoma. Am J Clin Pathol. 2009;132(5):699-706. [PMID:19846810] [https://doi.org/10.1309/AJCPV8LN5ENMZOVY].

 

 

 

 

 

 

 


Publication date:
09/26/2017

59ca37200e882500407c3060 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections