Autopsy and Case Reports
Autopsy and Case Reports
Article / Clinical Case Report

Spontaneous regression of a pulmonary adenocarcinoma after core needle biopsy

Cristiana Marques; Henrique Queiroga; Margarida Marques; Conceição Moura

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Spontaneous regression (SR) of cancer, especially lung cancer, is a rare biological event with a mechanism that is not currently understood. Immunological mechanisms seem to be the stronger explanation in SR of a lung cancer. We report the rare case of SR of a lung adenocarcinoma stage IA, in a 75-year-old man, which was incidentally diagnosed and histologically confirmed. Due to the patient’s comorbidities and his poor pulmonary function, stereotactic radiotherapy was scheduled. However, by the time the treatment was due to start, the tumor was no longer detectable.


Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Regression, Spontaneous


Kumar T, Patel N, Talwar A. Spontaneous regression of thoracic malignancies. Respir Med. 2010;104(10):1543-50. [PMID:20580882] [].

Everson TC, Cole WH. Spontaneous regression of cancer. Philadelphia: WB Saunders; 1966.

Cole WH. Efforts to explain spontaneous regression of cancer. J Surg Oncol. 1981;17(3):201-9. [PMID:6166811] [].

Menon MP, Eaton KD. Spontaneous regression of non-small-cell lung cancer in AIDS after immune reconstitution. J Thorac Oncol. 2015;10(1):e1-2. [PMID:25654731] [].

Inui M, Sano A, Asai I, Ito S, Tsuchiya T, Fukuda T. Spontaneous regression of small cell lung cancer. Cancer Treat Commun. 2015;3:21-3. [].

Lopez-Pastorini A, Plönes T, Brockmann M, Ludwig C, Beckers F, Stoelben E. Spontaneous regression of non-small cell lung cancer after biopsy of a mediastinal lymph node metastasis: a case report. J Med Case Reports. 2015;9(1):217. [].

Kitai H, Sakakibara-Konishi J, Oizumi S, et al. Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy. Lung Cancer. 2015;87(1):73-6. [PMID:25468200] [].

Choi SM, Go H, Chung D, Yim JJ. Spontaneous regression of squamous cell lung cancer. Am J Respir Crit Care Med. 2013;188(4):e5-6. [PMID:23947528] [].

Furukawa M, Oto T, Yamane M, Toyooka S, Kiura K, Miyoshi S. Spontaneous regression of primary lung cancer arising from an emphysematous bulla. Ann Thorac Cardiovasc Surg. 2011;17(6):577-9. [PMID:21881362] [].

Mizuno T, Usami N, Okasaka T, Kawaguchi K, Okagawa T, Yokoi K. Complete spontaneous regression of non-small cell lung cancer followed by adrenal relapse. Chest. 2011;140(2):527-8. [PMID:21813532] [].

Gladwish A, Clarke K, Bezjak A. Spontaneous regression in advanced non-small cell lung cancer. BMJ Case Rep. 2010;2010(1):bcr0720103147. [PMID:22802473] [].

Mawhinney E, Gray O, McVerry F, McDonnell GV. Paraneoplastic sensorimotor neuropathy associated with regression of small cell lung carcinoma. BMJ Case Rep. 2010;2010(1):bcr0120091486. [PMID:22802230] [].

Nakamura Y, Noguchi Y, Satoh E, et al. Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity. Lung Cancer. 2009;65(1):119-22. [PMID:19193472] [].

Agarwal P, Kapoor A, Khan A, Agarwal V. Spontaneous regression of an untreated lung cancer. Indian J Thorac Cardiovasc Surg. 2010;26(2):173-5. [].

Lee YS, Kang H, Jang P, et al. Spontaneous regression of small cell lung cancer. Respirology. 2008;13(4):615-8. [PMID:18422866] [].

Hirano S, Nakajima Y, Morino E, et al. A case of spontaneous regression of small cell lung cancer with progression of paraneoplastic sensory neuropathy. Lung Cancer. 2007;58(2):291-5. [PMID:17574297] [].

Pujol JL, Godard AL, Jacot W, Labauge P l. Spontaneous complete remission of a non-small cell lung cancer associated with anti-Hu antibody syndrome. J Thorac Oncol. 2007;2(2):168-70. [PMID:17410036] [].

Horino T, Takao T, Yamamoto M, Geshi T, Hashimoto K. Spontaneous remission of small cell lung cancer: a case report and review in the literature. Lung Cancer. 2006;53(2):249-52. [PMID:16790292] [].

Cafferata MA, Chiaramondia M, Monetti F, Ardizzoni A. Complete spontaneous remission of non-small-cell lung cancer: a case report. Lung Cancer. 2004;45(2):263-6. [PMID:15246199] [].

Kappauf H, Gallmeier WM, Wünsch PH, et al. Complete spontaneous remission in a patient with metastatic non-small-cell lung cancer. Ann Oncol. 1997;8(10):1031-9. [PMID:9402178] [].

Sengupta N, MacFie TS, MacDonald TT, Pennington D, Silver AR. Cancer immunoediting and “spontaneous” tumor regression. Pathol Res Pract. 2010;206(1):1-8. [PMID:19945228] [].

Papac RJ. Spontaneous regression of cancer. Cancer Treat Rev. 1996;22(6):395-423. [PMID:9134002] [].








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