Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2017.002
Autopsy and Case Reports
Article / Clinical Case Report

Small cell neuroendocrine carcinoma of the nasopharynx: a rare case report

Daniela Azevedo, Elisabete Rios, Lurdes Vendeira, Cristina Sarment

Downloads: 12
Views: 957

Abstract

Small cell neuroendocrine carcinoma rarely appears primarily in the head and neck and exhibits aggressive behavior with a poor prognosis. The pathologist has a significant role in the diagnosis, and a consensual treatment still does not exist. The authors report the case of a middle-aged male patient who presented repeated episodes of massive epistaxis. The diagnostic work-up disclosed the diagnosis of small cell neuroendocrine carcinoma of the nasopharynx. The patient was treated with chemotherapy followed by radiotherapy. Imaging examinations performed after the end of treatment showed apparent complete remission of the disease. The patient was kept under active surveillance with no signs of local relapse or distant metastasis after 4 years of follow-up.

Keywords

Carcinoma, Small Cell; Neuroendocrine, Carcinoma; Nasopharynx

References

1. Levenson RM Jr, Ihde DC, Matthews MJ, et al. Small cell carcinoma presenting as an extrapulmonary neoplasm: sites of origin and response to chemotherapy. J Natl Cancer Inst. 1981. 67(3):607-12. PMid:6268879.

2.  Remick SC, RuckdeschelJC. Extrapulmonary and pulmonary small-cell carcinoma: tumor biology, therapy, and outcome. Med Pediatr Oncol. 1992;20(2):89-99. PMid:1310345.http://dx.doi.org/10.1002/mpo.2950200202.

3.  Haider K, Shahid RK, Finch D, et al. Extrapulmonary small cell cancer: a Canadian province’s experience. Cancer. 2006. 107(9):2262-9. PMid:16998932. http://dx.doi.org/10.1002/cncr.22235.

4.  Brenner B, Shah MA, Gonen M, Klimstra DS, Shia J, Kelsen DP. Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases.Br J Cancer. 2004;90(9):1720- 6.  PMid:15150595.

5.  Shahab N. Extrapulmonary small cell carcinoma of the bladder. Semin Oncol. 2007;34(1):15-21. PMid:17270661. http://dx.doi.org/10.1053/j.seminoncol.2006.10.025.

6.  Lee SS, Lee JL, Ryu MH, et al. Extrapulmonary small cell carcinoma: single center experience with 61 patients. Acta Oncol. 2007;46(6):846-51. PMid:17653910. http://dx.doi.org/10.1080/02841860601071893.

7.  Ferlito A, Rinaldo A. Primary and secondary small cell neuroendocrine carcinoma of the larynx: a review. Head Neck. 2008;30(4):518-24. PMid:18302254. http://dx.doi.org/10.1002/hed.20797.

8.  Lin IH, Hwang CF, Huang HY, Chien CY. Small cell carcinoma of the nasopharynx. Acta Otolaryngol. 2007. 127(2):206-8. PMid:17364353. http://dx.doi.org/10.1080/00016480500401027.

9.  Deviprasad S, Rajeshwari A, Tahir M, Adarsha TV, Gangadhara S. Small cell neuroendocrine carcinoma originating from the lateral nasopharyngeal wall. Ear Nose Throat J. 2008;87(11):E1-3. PMid:19006052.

10.  Subha S. Neuroendocrine carcinoma of the nasopharynx: a case report. Med Health Sci J. 2011;9(5):101-3. http://dx.doi.org/10.15208/mhsj.2011.185.

11.  Lee LY, Chang KP, Hsu CL, Chen TC, Kuo TT. Small-cell neuroendocrine carcinoma of the nasopharynx: report of a rare case lacking association with Epstein-Barr virus. Int J Surg Pathol. 2011;19(2):199-202. PMid:18508843. http://dx.doi.org/10.1177/1066896908316904.

12.  Shunyu N, Lynrah Z, Goyal A, Raphal V. Small-cell neuroendocrine carcinoma of nasopharynx. Clin Rhinol Int J. 2012;5:130-1. http://dx.doi.org/10.5005/jp-journals-10013-1134.

13.  Takahashi S, Miyashita T, Hoshikawa H, Haba R, Togami T, Shibata T. Accelerated hyperfractionated radiotherapy for small cell carcinoma of the nasopharynx. Head Neck. 2015;37(5):E63-5. PMid:25270910. http://dx.doi.org/10.1002/hed.23888.

14.  Aguiar A, Jacome M, Azevedo I, Monteiro E, Castro V. Small-Cell neuroendocrine carcinoma originating from the nasopharynx: report of a rare case. Rep Radiother Oncol. 2015. 2(3):e3814.

15.  Bellahammou K, Lakhdissi A, Akkar O, Kouhen F, Rais F, Dahraoui S, Mrabti H, Errihani H. Small-cell neuroendocrine carcinoma of nasopharynx: a case report. IJSM 2016 Sep 25. [Epub ahead of print].

16.  Pan JJ, Ng WT, Zong JF, et al. Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy. Cancer. 2016. 122(4):546-58. PMid:26588425. http://dx.doi.org/10.1002/cncr.29795.

17.  Montone KT. The differential diagnosis of sinonasal/ nasopharyngeal neuroendocrine/neuroectodermally derived tumors. Arch Pathol Lab Med. 2015;139(12):1498-507. PMid:26619022. http://dx.doi.org/10.5858/arpa.2014- 0383. RA.

18.  Perez-Ordonez B. Neuroendocrine tumors. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005.  p. 26-27. World Health Organization Classification of Tumours, 9.

19.  Xu B, Chetty R, Perez-Ordonez B. Neuroendocrine neoplasms of the head and neck: some suggestions for the new WHO classification of head and neck tumors. Head Neck Pathol. 2014;8(1):24-32. PMid:24595420. http://dx.doi.org/10.1007/s12105-014-0531-y.

20.  Mitchell EH, Diaz A, Yilmaz T, et al. Multimodality treatment for sinonasal neuroendocrine carcinoma. Head Neck. 2012. 34(10):1372-6. PMid:22052583. http://dx.doi.org/10.1002/hed.21940.

21.  van der Laan TP, BijHP, van Hemel BM, et al. The importance of multimodality therapy in the treatment of sinonasal neuroendocrine carcinoma. Eur Arch Otorhinolaryngol. 2013. 270(9):2565-8. PMid:23740425. http://dx.doi.org/10.1007/s00405-013-2554-5.


Publication date:
03/31/2017

58de3fea0e88258c7658baed autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections