Autopsy and Case Reports
Autopsy and Case Reports
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A huge ovarian mucinous cystadenoma causing virilization, preterm labor, and persistent supine hypotensive syndrome during pregnancy

Suna Kabil Kucur, Canan Acar, Osman Temizkan, Aysim Ozagari, Ilay Gozukara, Atif Akyol

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Mucinous cystadenoma (MC) of the ovary is an unilateral, multilocular cystic benign epithelial tumor. Supposed to be hormone responsive, MC reaches huge sizes during pregnancy. Aortocaval compression is common during pregnancy, especially when the pregnant woman is in the supine position. However, the compression recovers with a change in position. The authors report the first case of a huge mucinous cystadenoma of the ovary complicating pregnancy and causing virilization, premature labor, and persistent supine hypotensive syndrome.


Pregnancy, Cystadenoma, Mucinous, Ovary, Virilism, Obstetric Labor, Premature


1. Leiserowitz GS. Managing ovarian masses during pregnancy. Obstet Gynecol Surv. 2006;61(7):463-70. PMid:16787549.

2. Usui R, Minakami H, Kosuge S, Iwasaki R, Ohwada M, Sato I. A retrospective survey of clinical, pathologic, and prognostic features of adnexal masses operated on during pregnancy. J Obstet Gynaecol Res. 2000;26(2):89-93. PMid:10870299.

3. Sherard GB 3rd, Hodson CA, Williams HJ, Semer DA, Hadi HA, Tait DL. Adnexal masses and pregnancy: a 12-year experience. Am J Obstet Gynecol. 2003;189(2):358-62, discussion 362-3. PMid:14520194.

4. Zanotti KM, Belinson JL, Kennedy AW. Treatment of gynecologic cancers in pregnancy. Semin Oncol. 2000;27(6):686-98. PMid:11130476.

5. Qublan HS, Al-Ghoweri AS, Al-Kaisi NS, Abu-Khait SA. Benign mucinous cystadenoma with stromal luteinization during pregnancy: a hormonally responsive tumor and a rare cause of fetal intrauterine growth restriction. J Obstet Gynaecol Res. 2002;28(2):104-7. PMid:12078969.

6. Ioffe OB, Simsir A, Silverberg SG. Pathology. In: Berek JS, Hacker NF, editors. Practical gynecologic oncology. Los Angeles: Lippincott Williams & Wilkins; 2000. p. 213-4.

7. AgarwalN, Parul, KriplaniA, BhatlaN, GuptaA. Management and outcome of pregnancies complicated with adnexal masses. Arch Gynecol Obstet. 2003;267(3):148-52. PMid:12580154.

8. Bolat F, ParlakgumusA, CanpolatT, TuncerI. Benign mucinous cystadenoma with stromal luteinization responsible for maternal virilization and fetal intrauterine growth restriction. J Obstet Gynaecol Res. 2011;37(7):893-6. PMid:21450020.

9. NoreenH, Syed S, Chaudhri R, Kahloon LE. A large unilocular mucinous cystadenoma in third trimester of pregnancy.J Coll Physicians Surg Pak. 2011;21(7):426-8. PMid:21777533.

10. Ivanov S, Kovachev E, Minkov R, et al. A rare case of pregnancy combined with a large ovarian tumour. Akush Ginekol (Sofiia). 2012;51(Suppl 1):29-32. PMid:23236676.

11. Pather S, Atkinson K, Wang I, Russell P, Kesby G, Carter J. Virilization in pregnancy due to a borderline mucinous ovarian tumor. J Obstet Gynaecol Res. 2007;33(3):384-7. PMid:17578373.

12. MacDonald PC, Grodin JM, Edman CD, Vellios F, Siiteri PK. Origin of estrogen in a postmenopausal woman with a nonendocrine tumor of the ovary and endometrial hyperplasia. Obstet Gynecol. 1976;47(6):644-50. PMid:934553.

13. Verhoeven AT, Mastboom JL, van Leusden HA, van der Velden WH. Virilization in pregnancy coexisting with an ovarian mucinous cystadenoma: A case report and review of virilizing ovarian tumors in pregnancy. Obstet Gynecol Surv. 1973;28(9):597-622. PMid:4614154.

14. Cohen I, Altaras M, Lew S, Jaffe R, Ben-Aderet N. Huge mesenteric mucinous cystadenoma in normal pregnancy. Obstet Gynecol. 1988;71(6 Pt 2):1030-2. PMid:3374916.

15. TicaAA, TicaOS, SaftoiuA, CamenD, TicaVI. Large pancreatic mucinous cystic neoplasm during pregnancy: what should be done? Gynecol Obstet Invest. 2013;75(2):132-8. PMid:23343567.

16. Cauchy F, Lefevre JH, Mourra N, Parc Y, Tiret E, Balladur P. Mucinous cystadenoma of the mesocolon, a rare entity frequently presenting with features of malignity: two case reports and review of the literature. Clin Res Hepatol Gastroenterol. 2012;36(1):e12-6. PMid:22074643.

17. Balci O, Gezginc K, Karatayli R, Acar A, Celik C, Colakoglu MC. Management and outcomes of adnexal masses during pregnancy: A 6-year experience. J Obstet Gynaecol Res. 2008;34(4):524-8. PMid:18946936.

18. Lee GSR, Hur SY, Shin JC, Kim SP, Kim SJ. Elective vs. conservative management of ovarian tumors in pregnancy. Int J Gynaecol Obstet. 2004;85(3):250-4. PMid:15145260.

19. Antoniou N, Varras M, Akrivis C, Demou A, Bellou A, Stefanaki S. Mucinous cystadenoma of the ovary with functioning stroma and virilization in pregnancy: a case report and review of the literature. Clin Exp Obstet Gynecol. 2003;30(4):248-52. PMid:14664425.

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