Autopsy and Case Reports
Autopsy and Case Reports
Article / Autopsy Case Report

Pulmonary agenesis and respiratory failure in childhood

Paula Vanessa Valverde Dinamarco; Cesar Cilento Ponce

Downloads: 9
Views: 574


Pulmonary agenesis (PA) is a rare congenital anomaly, which may be unilateral or bilateral. Unilateral PA may be associated with nonspecific respiratory symptoms. We report the case of 5-month-old infant who presented a normal development until the age of 4 months when a respiratory infection caused an acute respiratory distress syndrome with a fatal outcome. The autopsy findings depicted the right lung agenesis without any other concomitant malformation. Although respiratory symptoms represent frequent complaints in pediatrics, the aim of this study is not only to draw attention to the unilateral pulmonary agenesis as a possible underlying malformation in children who present recurrent and severe respiratory symptoms, but also to report a case diagnosed at autopsy.


Lung agenesis, Respiratory Insufficiency, Autopsy


Sharma S, Kumar S, Yaduvanshi D, Chauhan D. Isolated unilateral pulmonary agenesis. Indian Pediatr. 2005;42(2):170-2. [PMID:15767714].

Kisku KH, Panigrahi MK, Sudhakar R, Nagarajan A, Ravikumar R, Daniel JR. Agenesis of lung: a report of two cases. Lung India. 2008;25(1):28-30. []. [PMID:20396661]

De Pozze S, Brescia MA, Amermon EE, Sharma KK. Agenesis of the Left Lung. Arch Pediatr. 1960;77:485-90.

Kumar B, Kandpal DK, Sharma C, Sinha DD. Right lung agenesis. Afr J Paediatr Surg. 2008;5(2):102-4. []. [PMID:19858680]

Say B, Carpenter NJ, Giacoia G, Jegathesan S. Agenesis of the lung associated with a chromosome abnormality (46,XX,2p+). J Med Genet. 1980;17(6):477-8. []. [PMID:7205432]

Malcon MC, Malcon CM, Cavada MN, Caruso PE, Real LF. Unilateral pulmonary agenesis. J Bras Pneumol. 2012;38(4):526-9. []. [PMID:22964938]

Biyyam DR, Chapman T, Ferguson MR, Deutsch G, Dighe MK. Congenital lung abnormalities: embryologic features, prenatal diagnosis, and postnatal radiologic-pathologic correlation. Radiographics. 2010;30(6):1721-38. []. [PMID:21071385]

Khurram MS, Rao SP, Vamshipriya A. Pulmonary agenesis: a case report with review of literature. Qatar Med J. 2013;2013(2):38-40. []. [PMID:25003063]

Bachh AA, Pulluri S, Beigh A, Raju C, Deshpande R. Pulmonary aplasia with unusual associations in a woman. Iran J Med Sci. 2014;39(2):148-51. [PMID:24644386].

Chou AK, Huang SC, Chen SJ, et al. Unilateral lung agenesis: detrimental roles of surrounding vessels. Pediatr Pulmonol. 2007;42(3):242-8. []. [PMID:17238192]

Zhang Y, Fan M, Ren WD, et al. Prenatal diagnosis of fetal unilateral lung agenesis complicated with cardiac malposition. BMC Pregnancy Childbirth. 2013;13(1):79. []. [PMID:23530545]


Publication date:

569538f464cc8b1a57053d76 autopsy Articles

Autops Case Rep

Share this page
Page Sections