Autopsy and Case Reports
Autopsy and Case Reports
Article / Clinical Case Report

Placental mesenchymal dysplasia: case report with gross and histological findings

Marcello Pecoraro Toscano; Regina Schultz

Downloads: 8
Views: 490


Placental mesenchymal dysplasia (PMD) is a rare placental disorder characterized by placental enlargement and areas of abnormal, enlarged, grape-like villi. This condition may resemble a partial hydatidiform mole and may occur associated with Beckwith–Wiedemann syndrome (BWS) or in phenotypically normal fetuses. There were 110 cases reported so far. We describe one case with typical gross and microscopic placental lesions.


Placenta, Placenta Diseases, Hydatidiform mole


Gibson BR, Muir-Padilla J, Champeaux A, Suarez ES. Mesenchymal dysplasia of the placenta. Placenta. 2004;25(7):671-2. []. [PMID:15193875]

Jauniaux E, Nicolaides KH, Hustin J. Perinatal features associated with placental mesenchymal dysplasia. Placenta. 1997;18(8):701-6. []. [PMID:9364606]

Ohyama M, Kojyo T, Gotoda H, Sato T, Ijiri R, Tanaka Y. Mesenchymal dysplasia of the placenta. Pathol Int. 2000;50(9):759-64. []. [PMID:11012992]

Pham T, Steele J, Stayboldt C, Chan L, Benirschke K. Placental mesenchymal dysplasia is associated with high rates of intrauterine growth restriction and fetal demise: A report of 11 new cases and a review of the literature. Am J Clin Pathol. 2006;126(1):67-78. []. [PMID:16753607]

Villar J, Cheikh Ismail L, Victora CG, et al. International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet. 2014;384(9946):857-68. []. [PMID:25209487]

Thompson JMD, Irgens LM, Skjaerven R, Rasmussen S. Placenta weight percentile curves for singleton deliveries. BJOG. 2007;114(6):715-20. []. [PMID:17516963]

Benirschke K, Kaufmann P, Baergen RN, editors. Pathology of the human placenta. New York: Springer; 2006. cap. 28; p. 1019-26. Normative values and tables.

Moscoso G, Jauniaux E, Hustin J. Placental vascular anomaly with diffuse mesenchymal stem villous hyperplasia. A new clinico-pathological entity? Pathol Res Pract. 1991;187(2-3):324-8. []. [PMID:1712473]

Li H, Li L, Tang X, Yang F, Yang KX. Placental mesenchymal dysplasia: a case of a normal-appearing fetus with intrauterine growth restriction. Int J Clin Exp Pathol. 2014;7(8):5302-7. [PMID:25197414].

Ohira S, Ookubo N, Tanaka K, et al. Placental mesenchymal dysplasia: chronological observation of placental images during gestation and review of the literature. Gynecol Obstet Invest. 2013;75(4):217-23. []. [PMID:23594446]

Paradinas FJ, Sebire NJ, Fisher RA, et al. Pseudo-partial moles: placental stem vessel hydrops and the association with Beckwith-Wiedemann syndrome and complete moles. Histopathology. 2001;39(5):447-54. []. [PMID:11737301]

Matsui H, Iitsuka Y, Yamazawa K, et al. Placental mesenchymal dysplasia initially diagnosed as partial mole. Pathol Int. 2003;53(11):810-3. []. [PMID:14629309]

Ogino S, Redline RW. Villous capillary lesions of the placenta: distinctions between chorangioma, chorangiomatosis, and chorangiosis. Hum Pathol. 2000;31(8):945-54. []. [PMID:10987255]

Milani D, Pezzani L, Tabano S, Miozzo M. Beckwith-Wiedemann and IMAGe syndromes: two very different diseases caused by mutations on the same gene. Appl Clin Genet. 2014;7:169-75. [PMID:25258553].

Lage JM. Placentomegaly with massive hydrops of placental stem villi, diploid DNA content, and fetal omphaloceles: possible association with Beckwith-Wiedemann syndrome. Hum Pathol. 1991;22(6):591-7. []. [PMID:1864589]


Publication date:

569696b964cc8b5cda711c10 autopsy Articles

Autops Case Rep

Share this page
Page Sections