Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2014.011
Autopsy and Case Reports
Article / Clinical Case Report

Ovarian adenosarcoma simulating a simple cyst in a young patient

Leonardo Gomes da Fonseca; Aloísio Felipe-Silva; Samanta Cabral Severino da Silva; Paulo Francisco Ramos Margarido; Elias Abdo Filho; Paulo Marcelo Gehm Hoff

Downloads: 5
Views: 375

Abstract

Müllerian adenosarcoma is a rare, mixed tumor that can occur throughout the female genital tract, but is most commonly found in the uterus. Ovarian adenosarcoma is rarer and has a poorer prognosis than uterine adenosarcoma. Data on the clinicopathological features of ovarian adenosarcoma are limited, and, due to its rarity, the management is controversial. The authors report a case of a 25-year-old patient who presented with recurrent abdominal pain. Sonography and laparotomy showed an ovarian cyst, and pathologic examination confirmed the diagnosis of cystic low-grade adenosarcoma. The patient remains free of recurrence 6 months after diagnosis. The authors call attention to the differential diagnosis of ovarian masses, especially in young patients, and to the lack of evidence on the management of this neoplasm in the literature.
 

Keywords

Mixed Tumor, Mullerian, Ovarian Neoplasms, Neoplasm Staging, Therapeutics

References

Morgan RJ Jr, Alvarez RD, Armstrong DKet al. Ovarian cancer, version 2.2013. J Natl Compr Canc Netw. 2013;11(10):1199-209. PMid: [PMID:24142821].

Clement PB, Scully RE. Müllerian adenosarcoma of the uterus. A clinicopathologic analysis of ten cases of a distinctive type of müllerian mixed tumor. Cancer. 1974;34(4):1138-49.http://dx.doi.org/ [https://doi.org/10.1002/1097-0142(197410)34:4<1138::AID-CNCR2820340425>3.0.CO;2-9]. PMid: [PMID:4371193]

Ostör AG, Fortune DW. Benign and low grade variants of mixed Müllerian tumour of the uterus. Histopathology. 1980;4(4):369-82.http://dx.doi.org/ [https://doi.org/10.1111/j.1365-2559.1980.tb02932.x]. PMid: [PMID:6253378]

Clement PB, Scully RE. Extrauterine mesodermal (müllerian) adenosarcoma: a clinicopathologic analysis of five cases. Am J Clin Pathol. 1978;69(3):276-83. PMid: [PMID:205129].

Bard ES, Bard DS, Vargas-Cortes F. Extrauterine Müllerian adenosarcoma; a clinicopathologic report of a case with distant metastases and review of the literature. Gynecol Oncol. 1978;6(3):261-74.http://dx.doi.org/ [https://doi.org/10.1016/0090-8258(78)90031-8]. PMid: [PMID:208932]

Gollard R, Kosty M, Bordin G, Wax A, Lacey C. Two unusual presentations of müllerian adenosarcoma: case reports, literature review, and treatment considerations. Gynecol Oncol. 1995;59(3):412-22.http://dx.doi.org/ [https://doi.org/10.1006/gyno.1995.9950]. PMid: [PMID:8522267]

Fayemi AO, Ali M, Braun EV. Müllerian adenosarcoma of the uterine cervix. Am J Obstet Gynecol. 1978;130(6):734-5. PMid: [PMID:205133].

Eichhorn JH, Young RH, Clement PB, Scully RE. Mesodermal (müllerian) adenosarcoma of the ovary: a clinicopathologic analysis of 40 cases and a review of the literature. Am J Surg Pathol. 2002;26(10):1243-58.http://dx.doi.org/ [https://doi.org/10.1097/00000478-200210000-00001]. PMid: [PMID:12360039]

Fox H, Harilal KR, Youell A. Müllerian adenosarcoma of the uterine body: a report of nine cases. Histopathology. 1979;3(3):167-80.http://dx.doi.org/ [https://doi.org/10.1111/j.1365-2559.1979.tb02994.x]. PMid: [PMID:468120]

D’Angelo E, Prat J. Pathology of mixed Müllerian tumours. Best Pract Res Clin Obstet Gynaecol. 2011;25(6):705-18.http://dx.doi.org/ [https://doi.org/10.1016/j.bpobgyn.2011.05.010]. PMid: [PMID:21742560]

Oda Y, Nakanishi I, Tateiwa T. Intramural müllerian adenosarcoma of the uterus with adenomyosis. Arch Pathol Lab Med. 1984;108(10):798-801. PMid: [PMID:6089698].

Mahoney AD, Waisman J, Zeldis LJ. Adenomyoma: a precursor of extrauterine Müllerian adenosarcoma? Arch Pathol Lab Med. 1977;101(11):579-84. PMid: [PMID:199134].

Mckay DC, Ellis JH, Marn CS. CT of mullerian adenosarcoma arising in endometriosis. Clin Imaging. 1993;17(3):204-6.http://dx.doi.org/ [https://doi.org/10.1016/0899-7071(93)90111-Y]. PMid: [PMID:8395963]

Inoue M, Fukuda H, Tanizawa O. Adenosarcomas originating from sites other than uterine endometrium. Int J Gynaecol Obstet. 1995;48(3):299-306.http://dx.doi.org/ [https://doi.org/10.1016/0020-7292(94)02267-3]. PMid: [PMID:7781874]

Stern RC, Dash R, Bentley RC, Snyder MJ, Haney AF, Robboy SJ. Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. Int J Gynecol Pathol. 2001;20(2):133-9.http://dx.doi.org/ [https://doi.org/10.1097/00004347-200104000-00004]. PMid: [PMID:11293158]

Al-Abbadi MA, Spanta R. Pathologic quiz case. A 34-year-old woman with abdominal pain and a large right multicystic ovarian mass. Mullerian adenosarcoma arising in an endometriotic cyst. Arch Pathol Lab Med. 2004;128(9):1057-8. PMid: [PMID:15335245].

Verschraegen CF, Vasuratna A, Edwards Cet al. Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience. Oncol Rep. 1998;5(4):939-44. PMid: [PMID:9625851].

McCluggage WG. Mullerian adenosarcoma of the female genital tract. Adv Anat Pathol. 2010;17(2):122-9.http://dx.doi.org/ [https://doi.org/10.1097/PAP.0b013e3181cfe732]. PMid: [PMID:20179434]

Tate Thigpen J, Blessing JA, DeGeest K, Look KY, Homesley HD, and the Gynecologic Oncology Group. Cisplatin as initial chemotherapy in ovarian carcinosarcomas: a Gynecologic Oncology Group study. Gynecol Oncol. 2004;93(2):336-339.http://dx.doi.org/ [https://doi.org/10.1016/j.ygyno.2004.01.007]. PMid: [PMID:15099942]

Baker TR, Piver MS, Lele SB, Tsukada Y. Stage I uterine adenosarcoma: a report of six cases. J Surg Oncol. 1988;37(2):128-32.http://dx.doi.org/ [https://doi.org/10.1002/jso.2930370213]. PMid: [PMID:2830437]

Le T, Krepart GV, Lotocki RJ, Heywood MS. Malignant mixed mesodermal ovarian tumor treatment and prognosis: a 20-year experience. Gynecol Oncol. 1997;65(2):237-40.http://dx.doi.org/ [https://doi.org/10.1006/gyno.1997.4625]. PMid: [PMID:9159331]

Kim HS, Ahn JH, Chung HH, et al. Impact of intraoperative rupture of the ovarian capsule on prognosis in patients with early-stage epithelial ovarian cancer: a meta-analysis. Eur J Surg Oncol. 2013;39(3):279-89. http://dx.doi.org/ [https://doi.org/10.1016/j.ejso.2012.12.003]

Bakkum-Gamez JN, Richardson DL, Seamon LG, et al. Influence of intraoperative capsule rupture on outcomes in stage i epithelial ovarian cancer. Obstet Gynecol. 2009;113(1):11-7. http://dx.doi.org/ [https://doi.org/10.1097/AOG.0b013e3181917a0c]

McCluggage WG. Mullerian adenosarcoma of the female genital tract. Adv Anat Pathol. 2010;17(2):122-9. http://dx.doi.org/ [https://doi.org/10.1097/PAP.0b013e3181cfe732]


 


Publication date:
01/13/2016

569696b264cc8b5cda711bf7 autopsy Articles

Autops Case Rep

Share this page
Page Sections