Autopsy and Case Reports
https://autopsyandcasereports.org/article/doi/10.4322/acr.2014.006
Autopsy and Case Reports
Article / Clinical Case Report

Granulosa cell tumor of the testis in a newborn

Oliver Rojas Claros; Américo Toshiaki Sakai; Horácio Consolmagno; Marcos de Paula Nogueira; Leonardo Abreu Testagrossa; Oscar Eduardo Hidetoshi Fugita

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Abstract

Testicular neoplasms are uncommon tumors of childhood. These tumors comprise the germ cell tumors, and other tumors that may originate from histological testicular components, which are unrelated to the germinal lineage. Among the latter are the sex cord-stromal tumors (SCST), an important entity in newborns. SCSTs comprise, among others, granulosa cell tumors, which are more common in the ovary, but in rare cases may develop in the testis. The prognosis is excellent since it is universally benign. Diagnosis, which is sometimes challenging, is usually made after orchiectomy and pathological examination, which is characterized by morphological features and positive expression of inhibin, calretinin, and vimentin, and negative for alpha-fetoprotein. The authors present the case of a newborn with a right enlarged testis detected during the first examination after birth. Ultrasonography showed a heterogeneous solid/cystic mass in the right testis, without retroperitoneal lymphadenopathy. A right inguinal orchiectomy was performed 21 hours after birth. Pathologic examination revealed a juvenile granulosa cell tumor of the right testicle. After 4 years of follow-up, as expected, the child presented an uneventful outcome.
 

Keywords

Sex Cord-Gonadal Stromal Tumors, Granulosa Cell Tumor, Testicular Neoplasms, Infant, Newborn, Testis

References

Coppes MJ, Rackley R, Kay R. Primary testicular and paratesticular tumors of childhood. Med Pediatr Oncol. 1994;22:329-40. http://dx.doi.org/ [https://doi.org/10.1002/mpo.2950220506]

Walsh TJ, Grady RW, Porter MP, Lin DW, Weiss NS. Incidence of testicular germ cell cancers in U.S. children: SEER program experience 1973 to 2000. Urology. 2006;68:402-5. PMid: [PMID:16904461]. http://dx.doi.org/ [https://doi.org/10.1016/j.urology.2006.02.045]

Schneider DT, Terenziani M, Cecchetto G, et al. Gonadal and extragonadal germ cell tumors. In: Schneider DT, Brecht IB, Oslon TA, et al., editors. Sex cord stromal tumors and rare gonadal tumors. Heidelberg: Springer; 2012. p. 327-402. PMid:22527330.

Harms D, Gottschalk I, Jänig U. Pathological anatomy of germ cell tumors (especially testicular tumors) in children. Klin Padiatr. 1983;195:181-9. PMid: [PMID:6876681]. http://dx.doi.org/ [https://doi.org/10.1055/s-2008-1034066]

Schneider DT, Jänig U, Calaminus G, Göbel U, Harms D. Ovarian sex cord-stromal tumors: a clinicopathologic study of 72 cases from the Kiel Pediatric Tumor Registry. Virchows Arch. 2003;443:549-60. PMid: [PMID:12910419]. http://dx.doi.org/ [https://doi.org/10.1007/s00428-003-0869-0]

Hofman M, Schlegel PG, Hippert Fet al. Testicular sex cord stromal tumors: Analysis of patientsfrom Makei study. Pediatr Blood Cancer. 2013;60:1651-5. PMid: [PMID:23733594]. http://dx.doi.org/ [https://doi.org/10.1002/pbc.24607]

Zugor V, Labanaris AP, Witt J, Seidler A, Weingärtner K, Schott GE. Congenital juvenile granulosa cell tumor of testis in Newborns. Anticancer research. 2010;30:1731-4. PMid: [PMID:20592370].

Crump WD. Juvenile granulosa cell (sex cord-stromal) tumor of fetal testis. J Urol. 1983;129:1057-8. PMid: [PMID:6854755].

Lawrence WD, Young RH and Scully RE: Juvenile granulosa cell tumor of the infantile testis. A report of 14 cases. Am J Surg Pathol. 1985;9:87-94. PMid: [PMID:3976984]. http://dx.doi.org/ [https://doi.org/10.1097/00000478-198502000-00003]

Shukla AR, Huff DS, Canning DAet al. Juvenile granulosa cell tumor of the testis: contemporary clinical management and pathological diagnosis. J Urol. 2004;171:1900-2. PMid: [PMID:15076304]. http://dx.doi.org/ [https://doi.org/10.1097/01.ju.0000120223.29924.3b]

Ross JH, Rybicki L, Kay R. Clinical behavior and a contemporary management algorithm for prepubertal testis tumors: a summary of the Prepubertal Testis Tumor Registry. J Urol. 2002;168:1675-8. http://dx.doi.org/ [https://doi.org/10.1016/S0022-5347(05)64386-8]

Chan YF, Restall P, Kimble R. Juvenile granulosa cell tumor of the testis: report of two cases in newborns. J Pediatr Surg. 1997;32:752-3. http://dx.doi.org/ [https://doi.org/10.1016/S0022-3468(97)90025-7]

Young RH. Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol. 2005;18:S81-S98. PMid: [PMID:15502809]. http://dx.doi.org/ [https://doi.org/10.1038/modpathol.3800311]

Nieto N, Torres-Valdiviedo MJ, Aguado Pet al. Juvenile granulosa cell tumor of the testis: case report and review of literature. Tumori. 2002;88:72-4. PMid: [PMID:12004856].

Thomas JC, Ross JH, Kay R. Stromal testis tumors in children: a report from the prepubertal testis tumor registry. J Urol. 2001;166:2338-40. http://dx.doi.org/ [https://doi.org/10.1016/S0022-5347(05)65583-8]

Uehling DT, Smith JE, Logan R, Hafez GR. Newborn granulosa cell tumor of the testis. J Urol. 1987;138:385-6. PMid: [PMID:2439713].

Young RH, Lawrence WD, Scully RE. Juvenile granulosa cell tumor - another neoplasm associated with abnormal chromosomes and ambiguous genitalia. A report of three cases. Am J Surg Pathol. 1985;9:737-43. PMid: [PMID:4061731]. http://dx.doi.org/ [https://doi.org/10.1097/00000478-198510000-00005]

Raju U, Fine G, Warrier R, Kini R, Weiss L. Congenital testicular juvenile granulosa cell tumor in a neonate with X/XY mosaicism. Am J Surg Pathol. 1986;10:577-83. http://dx.doi.org/ [https://doi.org/10.1097/00000478-198608000-00008]

Tanaka Y, Sasaki Y, Tachibana K, Suwa S, Terashima K, Nakatani Y. Testicular juvenile granulosa cell tumor in an infant with X/XY mosaicism clinically diagnosed as true hermaphroditism. Am J Surg Pathol. 1994;18:316-22. http://dx.doi.org/ [https://doi.org/10.1097/00000478-199403000-00013]

Teilum G, Albrechtsen R, Norgaard-Pedersen B. The histogenetic-embryologic basis for reappearance of alpha-fetoprotein in endodermal sinus tumors (yolk sac tumors) and teratomas. Acta Pathol Microbiol Scand. 1975;83:80-6.

Brewer JA, Tank ES. Yolk sac tumors and alpha-fetoprotein in first year of life. Urology. 1993;42:79-80. http://dx.doi.org/ [https://doi.org/10.1016/0090-4295(93)90347-D]

Bader D, Riskin A, Vafsi Oet al. Alpha-fetoprotein in the early neonatal period - a large sutudy and review of the literature. Clin Chim Acta. 2004;349:15-23. PMid: [PMID:15469851]. http://dx.doi.org/ [https://doi.org/10.1016/j.cccn.2004.06.020]

Hyvarinen M, Zeltzer P, Oh W, Stiehm ER. Influence of gestational age on serum levels of alpha-1 fetoprotein, IgG globulin, and albumin in newborn infants. J Pediatr.1973;82:430-7. http://dx.doi.org/ [https://doi.org/10.1016/S0022-3476(73)80116-7]

Caballero C, Vekemans M, Lopez del Campo JG, Robyn C. Serum alpha-fetoprotein in adults, in women during pregnancy, in children at birth, and during the first week of life: a sex difference. Am J Obstet Gynecol.1977;127:384-9. PMid:65129.

Ballieux BEPB, Weijl NI, Gelderblom H, van Pelt J, Osanto S. False-positive serum human chorionic gonadotropin (hCG) in a male patient with malignant germ cell tumor of the testis: a case report and review of literature. Oncologist. 2008,13:1149-54. PMid: [PMID:18984875]. http://dx.doi.org/ [https://doi.org/10.1634/theoncologist.2008-0159]

Pinto MM. Juvenile granulosa cell tumor of the infant testis: case report with ultrastructural observations. Pediatr Pathol. 1985;4:277-89. http://dx.doi.org/ [https://doi.org/10.3109/15513818509026901]

Nistal M, Redondo E, Paniagua R. Juvenile granulosa cell tumor of the testis. Arch Pathol Lab Med. 1988;112:1129-32. PMid: [PMID:3178427].

Fagin R, Berbescu E, Landis S, Strumpf K, Patil U. Juvenile granulosa cell tumor of the testis. Urology 2003;62:351. http://dx.doi.org/ [https://doi.org/10.1016/S0090-4295(03)00355-8]

Groisman GM, Dische MR, Fine EM, Unger PD. Juvenile granulosa cell tumor of the testis: a comparative immunohistochemical study with normal infantile gonads. Pediatr Pathol. 1993;13:389-400. http://dx.doi.org/ [https://doi.org/10.3109/15513819309048227]

Peterson C, Skoog S. Prenatal diagnosis of juvenile granulosa cell tumor of the testis. J Pediatr Urol. 2008;4:472-4 PMid: [PMID:18760677]. http://dx.doi.org/ [https://doi.org/10.1016/j.jpurol.2008.04.005]

Alexiev BA, Alaish SM, Sun CC. Testicular juvenile granulose cell tumor in a newborn: case report and review of the literature. Int J Sug Pathol. 2007;15:321-5. PMid: [PMID:17652550]. http://dx.doi.org/ [https://doi.org/10.1177/1066896907302423]


 


Publication date:
01/13/2016

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