Autopsy and Case Reports
http://autopsyandcasereports.org/article/doi/10.4322/acr.2018.052
Autopsy and Case Reports
Article / Clinical Case Report

Ameloblastoma with distinctive granular cell pattern: an 8 case study

Ana Maria Hoyos Cadavid; Tathyane Harumi Nakajima Teshima; Clóvis Antônio Lopes Pinto; Cláudia Malheiros Coutinho Camillo; Silvia Vanessa Lourenço

Downloads: 0
Views: 82

Abstract

Ameloblastoma with granular cell pattern (AGC) is classified as an unusual histological subtype of solid/multicystic ameloblastoma, characterized by granular changes in stellate-like cells located within the inner portion of the epithelial follicles. Studies have revealed that lysosomal overload causes cytoplasmic granularity; however, the mechanism involved remains poorly understood. Here we report on eight cases of granular cell ameloblastoma, in the posterior region of the mandible. The age of the patients included in this case series ranged from 35 -64 years old and 87.5% of cases occurred in non-Caucasians, with a slight gender predilection for men (62.5%). There was no evidence of recurrence, and the majority of the cases were treated with surgical resection (87.5%). All tumors displayed histopathological features consistent with the diagnosis of ameloblastoma with granular cell pattern.

Keywords

Ameloblastoma, Odontogenic Tumors, Neoplasms

References

Dave A, Arora M, Shetty VP, Saluja P. Granular cells in ameloblastoma: an enigma in diagnosis. Indian J Dent. 2015;6(4):211-4. 10.4103/0975-962X.165048.26752883

Wu Y-H, Chang JY-F, Wang Y-P, Chiang C-P. Langerhans cells in granular cell ameloblastoma. J Formos Med Assoc. 2017;114:781-2. 10.1016/j.jfma.2017.02.007.28284724

Hunasgi S, Koneru A, Chauhan DS, Guruprasad Y. Rare giant granular cell ameloblastoma: a case report and an immunohistochemical study. Case Rep Dent. 2013;2013:372781. 10.1155/2013/372781.23533826

Nikitakis NG, Tzerbos F, Triantafyllou K, Papadimas C, Sklavounou A. Granular cell ameloblastoma: an unusual histological subtype report and review of literature. J Oral Maxillofac Res. 2011;1(4):e3.24421980

Wright JM, Vered M. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol. 2017;11(1):68-77. 10.1007/s12105-017-0794-1.28247226

Etebarian A, Asareh F, Motahhary P. Granular cell type of a unicystic ameloblastoma: an unusual case and review of the literature. J Oral Maxillofac Pathol. 2014;18(2):331. 10.4103/0973-029X.140927.25328325

Jansari TR, Samanta S, Trivedi P, Shah MJ. Granular cell ameloblastoma of mandible. Indian J Pathol Microbiol. 2014;57(2):305-7. 10.4103/0377-4929.134725.24943773

Yamunadevi A, Madhushankari GS, Selvamani M, Basandi PS, Yoithapprabhunath TR, Ganapathy N. Granularity in granular cell ameloblastoma. J Pharm Bioallied Sci. 2014;6(5, Suppl 1):S16-20. 10.4103/0975-7406.137253.25210361

Reichart PA, Philipsen HP, Sonner S. Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol. 1995;31B(2):86-99. 10.1016/0964-1955(94)00037-5.7633291

Kameyama Y, Takehana S, Mizohata M, et al. A clinicopathological study of ameloblastomas. Int J Oral Maxillofac Surg. 1987;16(6):706-12. 10.1016/S0901-5027(87)80057-7.3125270

Hartman KS. Granular-cell ameloblastoma. Oral Surg Oral Med Oral Pathol. 1974;38(2):241-53. 10.1016/0030-4220(74)90063-2.4528580

Thillaikarasi R, Balaji J, Gupta B, et al. Cystic granular cell ameloblastoma. J Maxillofac Oral Surg. 2010;9(3):310-3. 10.1007/s12663-010-0083-y.22190813

Dina R, Marchetti C, Vallania G, Corinaldesi G, Eusebi V. Granular cell ameloblastoma: an immunocytochemical study. Pathol Res Pract. 1996;192(6):541-6. 10.1016/S0344-0338(96)80103-8.8857640

Kumamoto H, Ooya K. Immunohistochemical and ultrastructural investigation of apoptotic cell death in granular cell ameloblastoma. J Oral Pathol Med. 2001;30(4):245-50. 10.1034/j.1600-0714.2001.300409.x.11302245

Henriques ÁCG, Vasconcelos MG, Galvão HC, de Souza LB, de Almeida Freitas R. Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(4):468-75. 10.1016/j.tripleo.2011.05.033.21911204

Lapthanasupkul P, Poomsawat S, Chindasombatjaroen J. Investigation of basement membrane proteins in a case of granular cell ameloblastoma. Int J Oral Sci. 2012;4(1):45-9.22361945

Cranin AN, Bennett J, Solomon M, Quarcoo S. Massive granular cell ameloblastoma with metastasis: report of a case. J Oral Maxillofac Surg. 1987;45(9):800-4. 10.1016/0278-2391(87)90207-2.3476703

Hoke HF Jr, Harrelson AB. Granular cell ameloblastoma with metastasis to the cervical vertebrae: observations on the origin of the granular cells. Cancer. 1967;20(6):991-9. 10.1002/1097-0142(196706)20:6<991::AID-CNCR2820200609>3.0.CO;2-V.6026472

Tsukada Y, Delapava S, Pickren JW. Granular-cell ameloblastoma with metastasis to the lungs: report of a case and review of the literature. Cancer. 1965;18(7):916-25. 10.1002/1097-0142(196507)18:7<916::AID-CNCR2820180722>3.0.CO;2-T.14308241

Takahashi K, Kitajima T, Lee M, et al. Granular cell ameloblastoma of the mandible with metastasis to the third thoracic vertebra: a case report. Clin Orthop Relat Res. 1985;(197):171-80.4017332

Bansal A, Bhatnagar A, Saxena S. Metastasizing granular cell ameloblastoma. J Oral Maxillofac Pathol. 2012;16(1):122-4.22434948

 

 

 

5bbca1dc0e88258a22d262d3 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections