Autopsy and Case Reports
http://autopsyandcasereports.org/article/doi/10.4322/acr.2018.043
Autopsy and Case Reports
Article / Autopsy Case Report

Malignant ameloblastoma: a challenging diagnosis

Ayodeji Salami; Uchenna Ezenkwa; Mudashiru Salami; Mustapha Ajani; Clement Okolo

Abstract

Ameloblastoma is an uncommon and locally aggressive, benign, odontogenic tumor, with local recurrence when not adequately excised. A rare variant of this neoplasm with the benign features but accompanied with metastases has been described. This rare variant is malignant ameloblastoma and is known to have a poor prognosis. We present the case of a young woman who had recurrent mandibular tumors, which were resected twice and histologically reported as ameloblastoma. Four years later, she presented with pulmonary metastasis and atelectasis. A review of the literature on this very rare neoplasm was also performed.

Keywords

Ameloblastoma, Mediastinum, Neoplasm Metastasis, Pulmonary Atelectasis

References

McClary AC, West RB, McClary AC, et al. Ameloblastoma: a clinical review and trends in management. Eur Arch Otorhinolaryngol. 2016;273(7):1649-61. 10.1007/s00405-015-3631-8.25926124

Jayaraj G, Sherlin HJ, Ramani P, et al. Metastasizing ameloblastoma - a perennial pathological enigma? Report of a case and review of literature. J Craniomaxillofac Surg. 2014;42(6):772-9. 10.1016/j.jcms.2013.11.009.24342734

Ajagbe HA, Daramola JO. Ameloblastoma: a survey of 199 cases in the University of College Hospital, Ibadan, Nigeria. J Natl Med Assoc. 1987;79(3):324-7.3573061

Ladeinde AL, Ogunlewe MO, Bamgbose BO, et al. Ameloblastoma: analysis of 207 cases in a Nigerian teaching hospital. Quintessence Int. 2006;37(1):69-74.16429706

Kodati S, Majumdar S, Uppala D, Namana M. Ameloblastic carcinoma: a report of three cases. J Clin Diagn Res. 2016;10(10):23-5.27891485

Van Dam SD, Unni KK, Keller EE. Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience. J Oral Maxillofac Surg. 2010;68(12):2962-74. 10.1016/j.joms.2010.05.084.20970910

Dahlgren SE, Ekström C, Mossberg B. Mandibular ameloblastoma with pulmonary and mediastinal lymph node metastases. Acta Otolaryngol. 1971;72(3):220-4. 10.3109/00016487109122476.5113394

Georgakas I, Lazaridou M, Dimitrakopoulos I, et al. Pulmonary metastasis in a 65-year-old man with mandibular ameloblastoma: a case report and review of the literature. J Oral Maxillofac Surg. 2012;70(5):1109-13. 10.1016/j.joms.2011.04.011.21835527

Brown NA, Betz BL. Ameloblastoma: a review of recent molecular pathogenetic discoveries. Biomark Cancer. 2015;7(Suppl 2):19-24.26483612

 

 

 

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