Autopsy and Case Reports
http://autopsyandcasereports.org/article/doi/10.4322/acr.2018.018
Autopsy and Case Reports
Article / Clinical Case Report

Pleomorphic undifferentiated soft tissue sarcoma in patient with long standing inflammatory bowel disease

Loredana Labinac-Peteh; Robert Terlević; Božo Krušlin

Abstract

Inflammatory bowel disease (IBD) has been associated with the development of both gastrointestinal and extraintestinal malignancy. The role of therapy in the development of malignancy in IBD has been controversial. We present the case of a 40-year-old female patient with long-standing mild IBD, who developed an undifferentiated pleomorphic sarcoma of the inguinal region and provide a brief review of the relevant literature. While our case likely represents a coincidence of two unrelated pathological entities, clinicians should keep in mind the possibility of soft tissue sarcomas in patients chronically treated with anti-inflammatory agents.

Keywords

Crohn Disease, Sarcoma, Anti-inflammatory Agents, Neoplasms, Second Primary

References

Bridge JA , Hogendoorn P , Bridge JA , Fletcher CD . WHO classification of tumours of soft tissue and bone . Lyon : International Agency for Research on Cancer ; 2013 .

Fletcher CDM . Diagnostic histopathology of tumors . Philadelphia : Elsevier Health Sciences ; 2007 .

Chang M , Chang L , Chang HM , Chang F . Intestinal and extraintestinal cancers associated with inflammatory bowel disease . Clin Colorectal Cancer . 2018 ; 17 ( 1 ): e29 - 37 . 28712945

Nieminen U , Färkkilä M . Malignancies in inflammatory bowel disease . Scand J Gastroenterol . 2015 ; 50 ( 1 ): 81 - 9 . 10.3109/00365521.2014.992041 . 25523559

Beaugerie L . Inflammatory bowel disease therapies and cancer risk: where are we and where are we going? Gut . 2012 ; 61 ( 4 ): 476 - 83 . 10.1136/gutjnl-2011-301133 . 22157331

Long MD , Herfarth HH , Pipkin CA , Porter CQ , Sandler RS , Kappelman MD . Increased risk for non-melanoma skin cancer in patients with inflammatory bowel disease . Clin Gastroenterol Hepatol . 2010 ; 8 ( 3 ): 268 - 74 . 10.1016/j.cgh.2009.11.024 . 20005977

Madanchi M , Zeitz J , Barthel C , et al . Malignancies in patients with inflammatory bowel disease: a single-centre experience . Digestion . 2016 ; 94 ( 1 ): 1 - 8 . 10.1159/000447259 . 27318857

Wadhwa V , Lopez R , Shen B . Crohn’s disease is associated with the risk for thyroid cancer . Inflamm Bowel Dis . 2016 ; 22 ( 12 ): 2902 - 6 . 10.1097/MIB.0000000000000963 . 27846192

Hovde Ø , Høivik ML , Henriksen M , Solberg IC , Småstuen MC , Moum BA . Malignancies in patients with inflammatory bowel disease: results from 20 years of follow-up in the IBSEN study . J Crohn’s Colitis . 2016 ; 11 ( 5 ): 571 - 577 . 10.1093/ecco-jcc/jjw193 .

Katsanos KH , Roda G , McBride RB , Cohen B , Colombel J-F . Increased risk of oral cancer in patients with inflammatory bowel diseases . Clin Gastroenterol Hepatol . 2016 ; 14 ( 3 ): 413 - 20 . 10.1016/j.cgh.2015.09.041 . 26499929

Akutsu D , Mizokami Y , Suzuki H , et al . A rare case of colonic leiomyosarcoma in association with ulcerative colitis . Intern Med . 2016 ; 55 ( 19 ): 2799 - 803 . 10.2169/internalmedicine.55.6770 . 27725539

Butcher RO , Titi S , Limdi JK . Mesenchymal tumours, immunosuppression and inflammatory bowel disease: rare, real or fortuitous? J Crohns Colitis . 2011 ; 5 ( 6 ): 645 - 6 . 10.1016/j.crohns.2011.07.016 . 22115389

Chandran O , Madden K . Ewing’s sarcoma in a patient with crohn’s disease treated with adalimumab . Inflamm Bowel Dis . 2017 ; 23 : S76 .

Beaugerie L , Brousse N , Bouvier AM , et al . Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study . Lancet . 2009 ; 374 ( 9701 ): 1617 - 25 . 10.1016/S0140-6736(09)61302-7 . 19837455

Cetın B , Büyükberber S , Yilmaz IB , Yildiz R , Coşkun U , Beneklı M . Kaposi’s sarcoma in patients with ulcerative colitis receiving immunosuppressive drugs: report of a case . Turk J Gastroenterol . 2011 ; 22 ( 6 ): 621 - 5 . 10.4318/tjg.2011.0280 . 22287409

Rodríguez-Peláez M , Fernández-García MS , Gutiérrez-Corral N , et al . Kaposi’s sarcoma: an opportunistic infection by human herpesvirus-8 in ulcerative colitis . J Crohns Colitis . 2010 ; 4 ( 5 ): 586 - 90 . 10.1016/j.crohns.2010.03.006 . 21122564

Svrcek M , Tiret E , Bennis M , Guyot P , Fléjou J-F . KSHV/HHV8-associated intestinal kaposi’s sarcoma in patient with ulcerative colitis receiving immunosuppressive drugs: report of a case . Dis Colon Rectum . 2009 ; 52 ( 1 ): 154 - 8 . 10.1007/DCR.0b013e318197217f . 19273971

Jostins L , Ripke S , Weersma RK , et al . Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease . Nature . 2012 ; 491 ( 7422 ): 119 - 24 . 10.1038/nature11582 . 23128233

Radons J . The role of inflammation in sarcoma . In: Aggarwal BB , Sung B , Gupta SC . Inflammation and cancer . Basel : Springer ; 2014 . p. 259 - 313 .

 

 

 

 

 

 

 

5ad79a8d0e8825a370ead76e autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections