Autopsy and Case Reports
http://autopsyandcasereports.org/article/doi/10.4322/acr.2017.042
Autopsy and Case Reports
Article / Autopsy Case Report

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells reported in an asymptomatic patient: a rare case and literature review

Ramen Sakhi; Ameer Hamza; Muhammad Siddique Khurram; Warda Ibrar; Paul Mazzara

Abstract

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare and poorly described pancreatic malignancy. It is comprised of mononuclear, pleomorphic, and undifferentiated cells as well as osteoclast-like giant cells (OGC’s). It constitutes less than 1% of pancreatic non-endocrine neoplasia and is twice as likely to occur in females as in males. Its histopathologic properties remain poorly understood. It is suspected that UC-OGC is of epithelial origin that can then transition to mesenchymal elements. As part of this study, we describe a case of a malignant pancreatic neoplasm that was discovered in a 69-year old patient as an incidental finding. We also provide an overview of previously published data to highlight UC-OGC’s clinical and pathologic features.

Keywords

Adenocarcinoma, Carcinoma, Pancreatic Ductal, Osteoclasts, Pancreatic Neoplasms

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